Visuospatial Processing Deficits Linked to Posterior Brain Regions in Premanifest and Early Stage Huntington's Disease.
- Labuschagne, Izelle
- Cassidy, Amy Mulick
- Scahill, Rachael I
- Johnson, Eileanoir B
- Rees, Elin
- O'Regan, Alison
- Queller, Sarah
- Frost, Chris
- Leavitt, Blair R
- Dürr, Alexandra
- Roos, Raymond
- Owen, Gail
- Borowsky, Beth
- Tabrizi, Sarah J
- Stout, Julie C
- TRACK-HD Investigators
DOIAbstract
OBJECTIVES: Visuospatial processing deficits have been reported in Huntington's disease (HD). To date, no study has examined associations between visuospatial cognition and posterior brain findings in HD. METHODS: We compared 119 premanifest (55> and 64<10.8 years to expected disease onset) and 104 early symptomatic (59 stage-1 and 45 stage-2) gene carriers, with 110 controls on visual search and mental rotation performance at baseline and 12 months. In the disease groups, we also examined associations between task performance and disease severity, functional capacity and structural brain measures. RESULTS: Cross-sectionally, there were strong differences between all disease groups and controls on visual search, and between diagnosed groups...
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