Eukaryotic cells of multicellular organisms organize themselves into tissues where most of the volume is made up of extracellular space; this is filled with a complex meshwork of macromolecules called the Extracellular Matrix (ECM). ECM is something more than a mechanical and a structural support, because it can directly influence cell activities like cell growth, division and survival, cell migration, cell differentiation and apoptosis. Matrix Metalloproteinases (MMPs) have been recognized as the main responsible for degradation of ECM components and general tissue remodeling but recently also ADAM metalloproteinases, in the metzincins superfamily, have been associated with those processes; consequently they are attracting growing interest...
The extracellular matrix (ECM) plays many important physiological functions such as providing suppor...
A disintegrin and metalloprotease (ADAM)17 is a sheddase, capable of releasing the ectodomains of me...
Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specifi...
The selectivity of zinc-metalloproteases inhibitors is crucial as broad spectrum inhibitors can caus...
The extracellular matrix (ECM) is a complex structured network of secreted macromolecules and proteo...
Wei, ShuoMembers of the metzincin superfamily of metalloproteinases, including the disintegrin and m...
ADAM10 is a disintegrin metalloproteinase that processes amyloid precursor protein and ErbB ligands ...
AbstractA recombinant soluble form of the catalytic domain of human ADAM-10 was expressed as an Fc f...
ADAM8 as a membrane-anchored metalloproteinase-disintegrin is upregulated under pathological conditi...
AbstractThe ADAM family of proteases are type I transmembrane proteins with both metalloproteinase a...
By shedding a large number of proteins including growth factors, receptors and mediators of inflamma...
A recombinant soluble form of the catalytic domain of human ADAM-10 was expressed as an Fc fusion pr...
My Thesis project was focused on the study of new ADAMs and MMPs synthetic inhibitors. ADAMs and MMP...
Lack of effective targeted therapies often contributes to poor clinical outcomes of aggressive malig...
By mediating proteolytic shedding of several transmembrane proteins like growth factors, cytokines, ...
The extracellular matrix (ECM) plays many important physiological functions such as providing suppor...
A disintegrin and metalloprotease (ADAM)17 is a sheddase, capable of releasing the ectodomains of me...
Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specifi...
The selectivity of zinc-metalloproteases inhibitors is crucial as broad spectrum inhibitors can caus...
The extracellular matrix (ECM) is a complex structured network of secreted macromolecules and proteo...
Wei, ShuoMembers of the metzincin superfamily of metalloproteinases, including the disintegrin and m...
ADAM10 is a disintegrin metalloproteinase that processes amyloid precursor protein and ErbB ligands ...
AbstractA recombinant soluble form of the catalytic domain of human ADAM-10 was expressed as an Fc f...
ADAM8 as a membrane-anchored metalloproteinase-disintegrin is upregulated under pathological conditi...
AbstractThe ADAM family of proteases are type I transmembrane proteins with both metalloproteinase a...
By shedding a large number of proteins including growth factors, receptors and mediators of inflamma...
A recombinant soluble form of the catalytic domain of human ADAM-10 was expressed as an Fc fusion pr...
My Thesis project was focused on the study of new ADAMs and MMPs synthetic inhibitors. ADAMs and MMP...
Lack of effective targeted therapies often contributes to poor clinical outcomes of aggressive malig...
By mediating proteolytic shedding of several transmembrane proteins like growth factors, cytokines, ...
The extracellular matrix (ECM) plays many important physiological functions such as providing suppor...
A disintegrin and metalloprotease (ADAM)17 is a sheddase, capable of releasing the ectodomains of me...
Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specifi...