Add to ORKGabstract: Identifying disease biomarkers may aid in the early detection of breast cancer and improve patient outcomes. Recent evidence suggests that tumors are immunogenic and therefore patients may launch an autoantibody response to tumor associated antigens. Single-chain variable fragments of autoantibodies derived from regional lymph node B cells of breast cancer patients were used to discover these tumor associated biomarkers on protein microarrays. Six candidate biomarkers were discovered from 22 heavy chain-only variable region antibody fragments screened. Validation tests are necessary to confirm the tumorgenicity of these antigens. However, the use of single-chain variable autoantibody fragments presents a novel platform for diagnos...
AbstractBy definition, tumor biomarkers are selective molecules that can distinguish between patient...
Breast cancer is the most common cancer among women and accounts for 6% of all cancer deaths. Curren...
Breast cancer is a major cause of mortality in women; however, technologies for early stage screenin...
There is strong preclinical evidence that cancer, including breast cancer, undergoes immune surveill...
Protein array technology has begun to play a significant role in the study of protein-protein intera...
The identification of autoantibodies to tumor cell proteins by proteomics approaches has great poten...
Tumor antigens are responsible for initiating an immune response in cancer patients, and their ident...
There is an urgent need to identify relevant tumor markers showing high sensitivity and specificity ...
The recognition that human tumors stimulate the produc-tion of autoantibodies against autologous cel...
The use of antibodies as capture molecules in assays is a common practice. By either printing monocl...
Although autoantibodies have been recognized as participants in pathogenesis of tissue injury, the c...
Despite significant advances in breast imaging, the ability to accurately detect Breast Cancer (BC) ...
The identification of tumor antigens capable of eliciting an immune response in vivo may be an effe...
2-6 juin 2014International audienceBreast cancer is one of the most challenging diseases, endangerin...
Background: Tumor-associated antigens recognized by humoral effectors of the immune system are a ver...
AbstractBy definition, tumor biomarkers are selective molecules that can distinguish between patient...
Breast cancer is the most common cancer among women and accounts for 6% of all cancer deaths. Curren...
Breast cancer is a major cause of mortality in women; however, technologies for early stage screenin...
There is strong preclinical evidence that cancer, including breast cancer, undergoes immune surveill...
Protein array technology has begun to play a significant role in the study of protein-protein intera...
The identification of autoantibodies to tumor cell proteins by proteomics approaches has great poten...
Tumor antigens are responsible for initiating an immune response in cancer patients, and their ident...
There is an urgent need to identify relevant tumor markers showing high sensitivity and specificity ...
The recognition that human tumors stimulate the produc-tion of autoantibodies against autologous cel...
The use of antibodies as capture molecules in assays is a common practice. By either printing monocl...
Although autoantibodies have been recognized as participants in pathogenesis of tissue injury, the c...
Despite significant advances in breast imaging, the ability to accurately detect Breast Cancer (BC) ...
The identification of tumor antigens capable of eliciting an immune response in vivo may be an effe...
2-6 juin 2014International audienceBreast cancer is one of the most challenging diseases, endangerin...
Background: Tumor-associated antigens recognized by humoral effectors of the immune system are a ver...
AbstractBy definition, tumor biomarkers are selective molecules that can distinguish between patient...
Breast cancer is the most common cancer among women and accounts for 6% of all cancer deaths. Curren...
Breast cancer is a major cause of mortality in women; however, technologies for early stage screenin...