Add to ORKGAging affects endogenous stem cells in terms of functionality and numbers. In particular, during aging, the stemness property can decrease because of enhanced apoptotic cell death and senescence. In addition, aging and aging-related co-morbidities affect the paracrine activity of stem cells and the efficiency of their transplantation. Collectively, this leads to a reduction of the capacity of organs to repair themselves, possibly due to a reduced functional capability of stem cells. Therefore, major efforts have been invested to improve the repair capability of stem cells in aged individuals by overexpressing antisenescence and antiapoptotic genes. In this review, we describe critical genes and signaling pathways in stem cell aging and disc...
Abstract Aging impacts diseases and lifespan. With current knowledge of stem cells, it is feasible t...
Why biological age is a major risk factor for many of the most important human diseases remains myst...
Aging is characterized by a chronic functional decline of organ systems which leads to tissue dysfun...
Aging affects endogenous stem cells in terms of functionality and numbers. In particular, during agi...
Aging affects endogenous stem cells in terms of functionality and numbers. In particular, during agi...
Ischemic heart disease affects a majority of people, especially elderly patients. Recent studies hav...
Preservation of adult stem cells pools is critical for maintaining tissue homeostasis into old age. ...
BACKGROUND: Recent evidence suggested that we grow old partly because of our stem cells grow old as ...
Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially ass...
In many tissues, mammalian aging is associated with a decline in the replicative and functional capa...
Cardiovascular disease (CVD) presents a great burden for elderly patients, their caregivers, and hea...
Cardiac stem cells (CSC) from explanted decompensated hearts (E-CSC) are, with respect to those obta...
Cardiac stem cells (CSC) from explanted decompensated hearts (E-CSC) are, with respect to those obta...
Adult stem/progenitor are a small population of cells that reside in tissue-specific niches and poss...
Nowadays, it is clear that adult stem cells, also called as tissue stem cells, play a central role t...
Abstract Aging impacts diseases and lifespan. With current knowledge of stem cells, it is feasible t...
Why biological age is a major risk factor for many of the most important human diseases remains myst...
Aging is characterized by a chronic functional decline of organ systems which leads to tissue dysfun...
Aging affects endogenous stem cells in terms of functionality and numbers. In particular, during agi...
Aging affects endogenous stem cells in terms of functionality and numbers. In particular, during agi...
Ischemic heart disease affects a majority of people, especially elderly patients. Recent studies hav...
Preservation of adult stem cells pools is critical for maintaining tissue homeostasis into old age. ...
BACKGROUND: Recent evidence suggested that we grow old partly because of our stem cells grow old as ...
Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially ass...
In many tissues, mammalian aging is associated with a decline in the replicative and functional capa...
Cardiovascular disease (CVD) presents a great burden for elderly patients, their caregivers, and hea...
Cardiac stem cells (CSC) from explanted decompensated hearts (E-CSC) are, with respect to those obta...
Cardiac stem cells (CSC) from explanted decompensated hearts (E-CSC) are, with respect to those obta...
Adult stem/progenitor are a small population of cells that reside in tissue-specific niches and poss...
Nowadays, it is clear that adult stem cells, also called as tissue stem cells, play a central role t...
Abstract Aging impacts diseases and lifespan. With current knowledge of stem cells, it is feasible t...
Why biological age is a major risk factor for many of the most important human diseases remains myst...
Aging is characterized by a chronic functional decline of organ systems which leads to tissue dysfun...