Nonsense-mediated mRNA decay (NMD) is best known as a eukaryotic surveillance mechanism that targets mRNAs containing premature termination codons (PTCs) for degradation. Extending beyond its mRNA surveillance role, NMD also functions as a translation-dependent post-transcriptional regulator of gene expression affecting 3-10 % of all mRNAs, most of which do not contain a PTC. In mammalian cells the degradation of mRNAs targeted by NMD has been reported to involve both endonucleolytic cleavage mediated by SMG6 and exonucleolytic degradation mediated by the heterodimers SMG5-SMG7 or SMG5-PNRC2, respectively, with PNRC2 providing the link between mRNA surveillance and decapping. In an attempt to further investigate the exonucleolytic pathways...
Nonsense-mediated mRNA decay (NMD) was initially described as a quality control mechanism clearing t...
Nonsense-mediated mRNA decay (NMD) controls gene expression by eliminating mRNAs with premature or a...
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and rapidly degrades mR...
The term "nonsense-mediated mRNA decay" (NMD) originally described the degradation of mRNAs with pre...
International audienceDegradation of eukaryotic RNAs that contain premature termination codons (PTC)...
Despite over 30 years of research, the molecular mechanisms of nonsense-mediated mRNA decay (NMD) ar...
Nonsense-mediated mRNA decay (NMD) is an important mRNA surveillance system that maintains the integ...
Quality control mechanisms have evolved to guard the cell against defects in gene expression. The no...
Degradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly indepen...
Quality control mechanisms have evolved to guard the cell against defects in gene expression. The no...
Nonsense-mediated decay is well known by the lucid definition of being a RNA surveillance mechanism ...
AbstractNonsense-mediated mRNA decay (NMD) degrades mRNAs carrying premature translation termination...
The nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs carrying a premature trans...
The nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs carrying a premature trans...
Background: Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA surveillance mechanism that dete...
Nonsense-mediated mRNA decay (NMD) was initially described as a quality control mechanism clearing t...
Nonsense-mediated mRNA decay (NMD) controls gene expression by eliminating mRNAs with premature or a...
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and rapidly degrades mR...
The term "nonsense-mediated mRNA decay" (NMD) originally described the degradation of mRNAs with pre...
International audienceDegradation of eukaryotic RNAs that contain premature termination codons (PTC)...
Despite over 30 years of research, the molecular mechanisms of nonsense-mediated mRNA decay (NMD) ar...
Nonsense-mediated mRNA decay (NMD) is an important mRNA surveillance system that maintains the integ...
Quality control mechanisms have evolved to guard the cell against defects in gene expression. The no...
Degradation of nonsense mediated mRNA decay (NMD) substrates is carried out by two seemingly indepen...
Quality control mechanisms have evolved to guard the cell against defects in gene expression. The no...
Nonsense-mediated decay is well known by the lucid definition of being a RNA surveillance mechanism ...
AbstractNonsense-mediated mRNA decay (NMD) degrades mRNAs carrying premature translation termination...
The nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs carrying a premature trans...
The nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs carrying a premature trans...
Background: Nonsense-mediated mRNA decay (NMD) is a eukaryotic mRNA surveillance mechanism that dete...
Nonsense-mediated mRNA decay (NMD) was initially described as a quality control mechanism clearing t...
Nonsense-mediated mRNA decay (NMD) controls gene expression by eliminating mRNAs with premature or a...
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and rapidly degrades mR...