AIMS : To investigate whether Imiquimod (IMQ) as TLR7 ligand protects mice from colonic inflammation and the mechanisms underlying in such immunoregulatory conditions. METHODS : Murine colitis was induced to Balb/c mice by administration of trinitrobenzene sulfonic acid (TNBS) with or without daily intraperitoneal administration of IMQ. Colitis was evaluated by body weight decreases and by histological score. Also colonic mRNA expression was measured by RT-PCR. To confirm the induction of Regulatory T cells (Tregs) by type-1 IFN from pDCs, we generated mouse bone marrow-derived pDCs and co-cultured these with CD4(+) T cells isolated from mouse spleen with or without IMQ stimulation. Cytokine production in the culture supernatant was measure...
Background & Aims Mesenchymal stem cells (MSCs) are pluripotent cells that can promote expansion of ...
Background: T-cells are a main target for antiinflammatory drugs in inflammatory bowel disease. As t...
BACKGROUND & AIMS: Inflammatory bowel diseases are multifactorial diseases commonly treated with...
Imiquimod is a Toll-like receptor-7 agonist that regulates immunity and can be used as an immune adj...
BACKGROUND & AIMS: Priming of T cells by dendritic cells (DCs) in the intestinal mucosa and asso...
BACKGROUND & AIMS: Innate lymphoid cells (ILCs) are a heterogeneous group of mucosal inflammatory ce...
Objectives To investigate the effect of tumor necrosis factor ligand-related molecule 1A (TL1A) on t...
Background & Aims: Innate lymphoid cells (ILCs) are a heterogeneous group of mucosal inflammatory ce...
Introduction: Exacerbations of inflammatory bowel disease are thought to be related to concurrent in...
Background/Aim: Several reports have indicated that environmental factors and defects in innate immu...
<p>TNBS colitis was induced in FXR<sup>+/+</sup> and FXR<sup>−/−</sup> mice. Mice were administered ...
Background: Ulcerative colitis (UC) is a chronic inflammatory autoimmune disease with limited treatm...
Mycophenolate mofetil (MMF) is an alternative immunosuppressive agent that has been reported to be e...
Background and Aims: Regulatory Foxp3(+) CD4(+) T cells [Tregs] have been implicated in the control ...
Animal models reflective of ulcerative colitis (UC) remain a major challenge, and yet are crucial to...
Background & Aims Mesenchymal stem cells (MSCs) are pluripotent cells that can promote expansion of ...
Background: T-cells are a main target for antiinflammatory drugs in inflammatory bowel disease. As t...
BACKGROUND & AIMS: Inflammatory bowel diseases are multifactorial diseases commonly treated with...
Imiquimod is a Toll-like receptor-7 agonist that regulates immunity and can be used as an immune adj...
BACKGROUND & AIMS: Priming of T cells by dendritic cells (DCs) in the intestinal mucosa and asso...
BACKGROUND & AIMS: Innate lymphoid cells (ILCs) are a heterogeneous group of mucosal inflammatory ce...
Objectives To investigate the effect of tumor necrosis factor ligand-related molecule 1A (TL1A) on t...
Background & Aims: Innate lymphoid cells (ILCs) are a heterogeneous group of mucosal inflammatory ce...
Introduction: Exacerbations of inflammatory bowel disease are thought to be related to concurrent in...
Background/Aim: Several reports have indicated that environmental factors and defects in innate immu...
<p>TNBS colitis was induced in FXR<sup>+/+</sup> and FXR<sup>−/−</sup> mice. Mice were administered ...
Background: Ulcerative colitis (UC) is a chronic inflammatory autoimmune disease with limited treatm...
Mycophenolate mofetil (MMF) is an alternative immunosuppressive agent that has been reported to be e...
Background and Aims: Regulatory Foxp3(+) CD4(+) T cells [Tregs] have been implicated in the control ...
Animal models reflective of ulcerative colitis (UC) remain a major challenge, and yet are crucial to...
Background & Aims Mesenchymal stem cells (MSCs) are pluripotent cells that can promote expansion of ...
Background: T-cells are a main target for antiinflammatory drugs in inflammatory bowel disease. As t...
BACKGROUND & AIMS: Inflammatory bowel diseases are multifactorial diseases commonly treated with...