Add to ORKGData from 134 patients who were treated with clozapine are analysed in order to determine the influence of age, gender and comedication on the pharmacokinetics of clozapine. Serum concentration was corrected for the daily dose administered. Female patients had a statistically significant higher corrected serum concentration of clozapine than male patients. In female patients, corrected serum concentration tended to increase from <25 years to 45 years, then fall and increase again with increasing age. In young male patients (<25 years) a relatively high corrected serum concentration tended to increase with age. When a patient was also treated with benzodiazepines or tricyclic antidepressants, a significant higher corrected serum concentratio...
Background Clozapine is an effective drug for the management of schizophrenia that has not responde...
textabstractAbstract Metabolic syndrome during clozapine treatment Objective: To assess the prevalen...
Aim: To develop a combined population pharmacokinetic model (PPK) to assess the magnitude and variab...
Data from 134 patients who were treated with clozapine are analysed in order to determine the influe...
Data from 180 patients who were treated with clomipramine are analysed in order to quantify the infl...
[[abstract]]Background: Previous reports concerning the effects of gender and age on steady-state pl...
Abstract Background Clozapine is the most effective drug for treatment-resistant schizophrenia, and ...
Data from 180 patients who were treated with clomipramine are analysed in order to quantify the infl...
Objective To investigate serum concentrations of second-generation antipsychotics in relation to ag...
Michaela Mayerova,1–3 Libor Ustohal,1–3 Jiri Jarkovsky,4 Jan Pivnicka,1,5 Tomas Kasparek...
Objective Clozapine is the most powerful new-generation antipsychotic. Although this drug leads to g...
Steady-state plasma concentrations of clozapine and norclozapine, its major metabolite, as well as t...
Background and Objective. Clozapine is a second-generation antipsychotic drug that is considered the...
Neben Alter, Geschlecht, Rauchen und genetischen Polymorphismen der metabolischen Enzyme können vor ...
Background: Clozapine is a key antipsychotic drug for treatment-resistant schizophrenia but exhibits...
Background Clozapine is an effective drug for the management of schizophrenia that has not responde...
textabstractAbstract Metabolic syndrome during clozapine treatment Objective: To assess the prevalen...
Aim: To develop a combined population pharmacokinetic model (PPK) to assess the magnitude and variab...
Data from 134 patients who were treated with clozapine are analysed in order to determine the influe...
Data from 180 patients who were treated with clomipramine are analysed in order to quantify the infl...
[[abstract]]Background: Previous reports concerning the effects of gender and age on steady-state pl...
Abstract Background Clozapine is the most effective drug for treatment-resistant schizophrenia, and ...
Data from 180 patients who were treated with clomipramine are analysed in order to quantify the infl...
Objective To investigate serum concentrations of second-generation antipsychotics in relation to ag...
Michaela Mayerova,1–3 Libor Ustohal,1–3 Jiri Jarkovsky,4 Jan Pivnicka,1,5 Tomas Kasparek...
Objective Clozapine is the most powerful new-generation antipsychotic. Although this drug leads to g...
Steady-state plasma concentrations of clozapine and norclozapine, its major metabolite, as well as t...
Background and Objective. Clozapine is a second-generation antipsychotic drug that is considered the...
Neben Alter, Geschlecht, Rauchen und genetischen Polymorphismen der metabolischen Enzyme können vor ...
Background: Clozapine is a key antipsychotic drug for treatment-resistant schizophrenia but exhibits...
Background Clozapine is an effective drug for the management of schizophrenia that has not responde...
textabstractAbstract Metabolic syndrome during clozapine treatment Objective: To assess the prevalen...
Aim: To develop a combined population pharmacokinetic model (PPK) to assess the magnitude and variab...