Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids
- Liao, George P.
- Abdelraheem, Eman M. M.
- Neochoritis, Constantinos G.
- Kurpiewska, Katarzyna
- Kalinowska-Tłuścik, Justyna
- McGowan, David C.
- Dömling, Alexander
Publication date
October 2015
DOI Publisher
American Chemical Society (ACS)Abstract
The direct macrocycle synthesis of α-isocyano-ω-carboxylic acids via an Ugi multicomponent reaction is introduced. This multicomponent reaction (MCR) protocol differs by being especially short, convergent, and versatile, giving access to 12-22 membered rings
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