Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study.
- Murdoch, David R
- Corey, G Ralph
- Hoen, Bruno
- Miró, Jose M
- Fowler, Vance G
- Bayer, Arnold S
- Karchmer, Adolf W
- Olaison, Lars
- Pappas, Paul A
- Moreillon, Philippe
- Chambers, Stephen T
- Chu, Vivian H
- Falcó, Vicenc
- Holland, David J
- Jones, Philip
- Klein, John L
- Raymond, Nigel J
- Read, Kerry M
- Tripodi, Marie F
- Utili, Riccardo
- Wang, Andrew
- Woods, Christopher W
- Cabell, Christopher CH
- International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators,
DOIAbstract
BACKGROUND: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. METHODS: Prospective cohort study of 2781 adults with definite IE who were admitted to 58 hospitals in 25 countries from June 1, 2000, through September 1, 2005. RESULTS: The median age of the cohort was 57.9 (interquartile range, 43.2-71.8) years, and 72.1% had native valve IE. Most patients (77.0%) presented early in the disease (<30 days) with few of the classic clinical hallmarks of IE. Recent health care exposure was found in one-quarter of patients. Staphylococcus aureus was the most common pathogen (31.2%). The mitral (41.1%) and aortic (37.6%) v...
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