Underestimate of tonometric readings after photorefractive keratectomy increases at higher intraocular pressure levels

PURPOSE: To determine whether tonometric readings of increases in intraocular pressure (IOP) during the water-drinking test (WDT) are affected by variations in central corneal thickness (CCT) induced by photorefractive keratectomy (PRK). METHODS: Data from 30 randomly selected eyes of 30 patients (18 men and 12 women; mean age, +/- SD: 33.9 +/- 7.6 years) undergoing bilateral PRK for myopia (-6.57 +/- 2.39 D) were obtained. Objective refraction, anterior radius of corneal curvature (R), CCT, and IOP measurements at baseline and at different time intervals after ingestion of 1 L of water within 5 minutes, were performed before and 6 months after PRK. All measured IOPs were recalculated by a correction factor for R and CCT and expressed as corrected intraocular pressure (IOPC) measurements. RESULTS: The mean R +/- SD was 7.84 +/- 0.20 and 8.76 +/- 0.34 mm, and the mean CCT was 544.83 +/- 19.69 and 453.97 +/- 29.95 microm, before and after PRK, respectively. The mean IOP at baseline was 15.05 +/- 2.78 and 9.83 +/- 2.56 mm Hg, and during WDT was 18.32 +/- 3.42 and 11.42 +/- 3.10 mm Hg at 10 minutes, 18.59 +/- 2.99 and 11.54 +/- 2.54 mm Hg at 20 minutes, 17.80 +/- 2.85 and 10.87 +/- 2.22 mm Hg at 30 minutes, 16.35 +/- 3.02 and 10.26 +/- 2.21 mm Hg at 45 minutes, and 14.90 +/- 2.52 and 9.81 +/- 2.32 mm Hg at 60 minutes, before and after PRK, respectively. The mean IOPC at baseline was 13.64 +/- 2.33 and 13.05 +/- 2.98 mm Hg, and during WDT was 16.61 +/- 2.77 and 15.08 +/- 3.59 mm Hg at 10 minutes, 16.96 +/- 2.69 and 15.33 +/- 2.96 mm Hg at 20 minutes, 16.10 +/- 2.50 and 14.42 +/- 2.60 mm Hg at 30 minutes, 14.92 +/- 2.72 and 13.62 +/- 2.65 mm Hg at 45 minutes, 13.82 +/- 2.27 and 13.05 +/- 2.55 mm Hg at 60 minutes, before and after excimer laser treatment, respectively. Pre- and postoperative IOPs and percentages of IOP increase differed significantly (P < 0.05), in particular at the peak, as did IOPCs but not the percentages of increase in IOPC, apart from the highest values. CONCLUSIONS: Corneal changes after PRK for myopia may induce an uneven underestimate of the IOP increases. The inadequacy of a correction factor to compensate for CCT and R at high IOP levels indicates that other biomechanical factors may play a role when the cornea is subjected to dynamic actual IOP variation. Such increase of the well-known underestimate of IOP after PRK at higher actual IOPs may have significant clinical implications in tonometric assessment of subjects at risk of glaucomatous damage