Preterm birth (PTB) is firmly linked to inflammation regardless of the presence of infection. Proinflammatory cytokines, including IL-1β, are produced in gestational tissues and can locally upregulate uterine activation proteins. Premature activation of the uterus by inflammation may lead to PTB, and IL-1 has been identified as a key inducer of this condition. However, all currently available IL-1 inhibitors are large molecules that exhibit competitive antagonism properties by inhibiting all IL-1R signaling, including transcription factor NF-κB, which conveys important physiological roles. We hereby demonstrate the efficacy of a small noncompetitive (all-d peptide) IL-1R-biased ligand, termed rytvela (labeled 101.10) in delaying IL-1β-, TLR...
Preterm labour (PTL) is commonly associated with infection and/or inflammation. Lipopolysaccharide (...
Inflammatory mechanisms have a critical role in parturition, which results from a gathering of diffe...
Preterm labour (PTL) is commonly associated with infection and/or inflammation. Lipopolysaccharide (...
Preterm birth (PTB) is commonly accompanied by in utero fetal inflammation, and existing tocolytic d...
Inflammatory activation, a major driver of preterm birth and subsequent neonatal morbidity, is an at...
Objectives Preterm birth (PTB) occurs in 5% to 18% of newborns. However, the underlying inflammatory...
Preterm birth (PTB) is a major cause of neonatal mortality and morbidity, often triggered by chorioa...
A pro-inflammatory signalling cascade initiates the events that bring about parturition, including u...
An inflammatory response is instrumental in the physiological process of parturition but the upstrea...
Spontaneous preterm labor is frequently caused by an inflammatory response in the gestational tissue...
Prophylactic administration of a Broad-Spectrum Chemokine Inhibitor (BSCI) led to the suppression of...
Every year, 15 million pregnancies end prematurely, resulting in more than 1 million infant deaths a...
Preterm birth (PTB) is the single most important cause of perinatal and infant mortality worldwide. ...
Spontaneous preterm labor is frequently caused by an inflammatory response in the gestational tissue...
Preterm birth is the largest single cause of neonatal death and morbidity. By activating cytokine- a...
Preterm labour (PTL) is commonly associated with infection and/or inflammation. Lipopolysaccharide (...
Inflammatory mechanisms have a critical role in parturition, which results from a gathering of diffe...
Preterm labour (PTL) is commonly associated with infection and/or inflammation. Lipopolysaccharide (...
Preterm birth (PTB) is commonly accompanied by in utero fetal inflammation, and existing tocolytic d...
Inflammatory activation, a major driver of preterm birth and subsequent neonatal morbidity, is an at...
Objectives Preterm birth (PTB) occurs in 5% to 18% of newborns. However, the underlying inflammatory...
Preterm birth (PTB) is a major cause of neonatal mortality and morbidity, often triggered by chorioa...
A pro-inflammatory signalling cascade initiates the events that bring about parturition, including u...
An inflammatory response is instrumental in the physiological process of parturition but the upstrea...
Spontaneous preterm labor is frequently caused by an inflammatory response in the gestational tissue...
Prophylactic administration of a Broad-Spectrum Chemokine Inhibitor (BSCI) led to the suppression of...
Every year, 15 million pregnancies end prematurely, resulting in more than 1 million infant deaths a...
Preterm birth (PTB) is the single most important cause of perinatal and infant mortality worldwide. ...
Spontaneous preterm labor is frequently caused by an inflammatory response in the gestational tissue...
Preterm birth is the largest single cause of neonatal death and morbidity. By activating cytokine- a...
Preterm labour (PTL) is commonly associated with infection and/or inflammation. Lipopolysaccharide (...
Inflammatory mechanisms have a critical role in parturition, which results from a gathering of diffe...
Preterm labour (PTL) is commonly associated with infection and/or inflammation. Lipopolysaccharide (...