Cost effectiveness of Mohs micrographic surgery for non-melanoma skin cancer: a systematic review protocol

The overall research question for this systematic review is: what is the cost effectiveness of Mohs micrographic surgery for non-melanoma skin cancer? More specifically, the objectives are to: Examine the evidence on the cost effectiveness, cost benefit, cost minimization, and cost utility of Mohs micrographic surgery, compared to other surgical/ablative interventions such as excisional surgery and radiation therapy, as well as non-surgical/chemotherapeutic interventions such as topical 5-fluorouracil and imiquimod immunotherapy, for non-melanoma skin cancer clinical care outcomes; Determine the cost effectiveness, cost benefit, cost minimization and cost utility of Mohs micrographic surgery from the patient, provider, healthcare system and societal perspectives in order to elucidate the economic and clinical benefits of the procedure at these various levels; Provide a comprehensive assessment of the relative economic and clinical effectiveness of this procedure for patients with non-melanoma skin cancer in different contexts globally.Yuri Tertilus Jadotte, Yifan Xue, Philip J Cohen, Robert A Schwartz, Cheryl Holly, Susan W Salmon