Integrin-linked kinase (ILK) was identified by its interaction with the cytoplasmic tail of human β1 integrin and previous data suggest that ILK is a component of diverse signaling pathways, including integrin, Wnt, and protein kinase B. Here we show that the absence of ILK function in Drosophila causes defects similar to loss of integrin adhesion, but not similar to loss of these signaling pathways. ILK mutations cause embryonic lethality and defects in muscle attachment, and clones of cells lacking ILK in the adult wing fail to adhere, forming wing blisters. Consistent with this, an ILK–green fluorescent protein fusion protein colocalizes with the position-specific integrins at sites of integrin function: muscle attachment sites and the b...
<div><p>A variety of human diseases arise from mutations that alter muscle contraction. Evolutionary...
Mutations in kakapo were recovered in genetic screens designed to isolate genes required for integri...
AbstractBackground: Mammalian integrin-linked kinase (ILK) was identified in a yeast two-hybrid scre...
My thesis is focused on the functional analysis of the molecular mechanism of theintegrin-linked kin...
AbstractThe Drosophila αPS2βPS integrin is required for diverse development events, including muscle...
In order to build a multi-cellular organism and to regulate cellular functions, cells need to commun...
SummaryIntegrins are critical for barrier epithelial architecture. Integrin loss in vertebrate skin ...
Copyright © 2015 Elsevier Ltd. All rights reserved.Integrins are critical for barrier epithelial arc...
AbstractRecent genetic studies in the worm Caenorhabditis elegans and fruitfly Drosophila have revea...
Integrin-linked kinase (Ilk) is a serine/threonine ki-nase and an adaptor protein that links integri...
The Drosophila alpha PS2 beta PS integrin is required for diverse development events, including musc...
AbstractIt is the precise connectivity between skeletal muscles and their corresponding tendon cells...
In Drosophila melanogaster the visceral mesoderm (VM) develops during embryogenesis in a process whe...
We show that the Drosophila gene rhea, isolated because its wing blister phenotype is typical of mut...
Integrin-mediated cell-matrix interactions are essential for development, tissue homeostasis, and re...
<div><p>A variety of human diseases arise from mutations that alter muscle contraction. Evolutionary...
Mutations in kakapo were recovered in genetic screens designed to isolate genes required for integri...
AbstractBackground: Mammalian integrin-linked kinase (ILK) was identified in a yeast two-hybrid scre...
My thesis is focused on the functional analysis of the molecular mechanism of theintegrin-linked kin...
AbstractThe Drosophila αPS2βPS integrin is required for diverse development events, including muscle...
In order to build a multi-cellular organism and to regulate cellular functions, cells need to commun...
SummaryIntegrins are critical for barrier epithelial architecture. Integrin loss in vertebrate skin ...
Copyright © 2015 Elsevier Ltd. All rights reserved.Integrins are critical for barrier epithelial arc...
AbstractRecent genetic studies in the worm Caenorhabditis elegans and fruitfly Drosophila have revea...
Integrin-linked kinase (Ilk) is a serine/threonine ki-nase and an adaptor protein that links integri...
The Drosophila alpha PS2 beta PS integrin is required for diverse development events, including musc...
AbstractIt is the precise connectivity between skeletal muscles and their corresponding tendon cells...
In Drosophila melanogaster the visceral mesoderm (VM) develops during embryogenesis in a process whe...
We show that the Drosophila gene rhea, isolated because its wing blister phenotype is typical of mut...
Integrin-mediated cell-matrix interactions are essential for development, tissue homeostasis, and re...
<div><p>A variety of human diseases arise from mutations that alter muscle contraction. Evolutionary...
Mutations in kakapo were recovered in genetic screens designed to isolate genes required for integri...
AbstractBackground: Mammalian integrin-linked kinase (ILK) was identified in a yeast two-hybrid scre...