Protein folding by the endoplasmic reticulum (ER) is physiologically critical; its disruption causes ER stress and augments disease. ER stress activates the unfolded protein response (UPR) to restore homeostasis. If stress persists, the UPR induces apoptotic cell death, but the mechanisms remain elusive. Here, we report that unmitigated ER stress promoted apoptosis through cell-autonomous, UPR-controlled activation of death receptor 5 (DR5). ER stressors induced DR5 transcription via the UPR mediator CHOP; however, the UPR sensor IRE1α transiently catalyzed DR5 mRNA decay, which allowed time for adaptation. Persistent ER stress built up intracellular DR5 protein, driving ligand-independent DR5 activation and apoptosis engagement via caspase...
Several studies implicate specific death receptors (DRs) and caspase-8 in mediating apoptosis i...
The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function and su...
The endoplasmic reticulum (ER) is an organelle in which newly synthesized secretory and transmembran...
Protein folding by the endoplasmic reticulum (ER) is physiologically critical; its disruption causes...
Disruption of protein folding homeostasis in the endoplasmic reticulum activates a signaling pathway...
Disruption of protein folding in the endoplasmic reticulum (ER) activates the unfolded protein respo...
One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation of the un...
One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation of the un...
One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation of the un...
One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation of the un...
AbstractEndoplasmic reticulum (ER) stress is a common feature of several physiological and pathologi...
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates a signaling cascad...
Glab et al.1 examined in a recent paper apoptosis induced by some drivers of endoplasmic reticulum ...
Protein-folding stress at the endoplasmic reticulum (ER) is a salient feature of specialized secreto...
The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function and su...
Several studies implicate specific death receptors (DRs) and caspase-8 in mediating apoptosis i...
The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function and su...
The endoplasmic reticulum (ER) is an organelle in which newly synthesized secretory and transmembran...
Protein folding by the endoplasmic reticulum (ER) is physiologically critical; its disruption causes...
Disruption of protein folding homeostasis in the endoplasmic reticulum activates a signaling pathway...
Disruption of protein folding in the endoplasmic reticulum (ER) activates the unfolded protein respo...
One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation of the un...
One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation of the un...
One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation of the un...
One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation of the un...
AbstractEndoplasmic reticulum (ER) stress is a common feature of several physiological and pathologi...
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates a signaling cascad...
Glab et al.1 examined in a recent paper apoptosis induced by some drivers of endoplasmic reticulum ...
Protein-folding stress at the endoplasmic reticulum (ER) is a salient feature of specialized secreto...
The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function and su...
Several studies implicate specific death receptors (DRs) and caspase-8 in mediating apoptosis i...
The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function and su...
The endoplasmic reticulum (ER) is an organelle in which newly synthesized secretory and transmembran...