International audienceNicotinic acetylcholine receptors (nAChRs) of α4β2 and α7 subtypes expressed in the brain neurons are involved in regulating memory and cognition. Their level is decreased upon several neurodegenerative disorders including Alzheimer's disease (AD), although the reasons for such a decrease are not completely understood. To test whether the nAChR-specific antibodies can affect the brain nAChRs and influence the behavior, we either immunized mice with recombinant extracellular domains of α4 and α7, subunits α4(1-209) and α7(1-208), or injected them with α7(1-208)-specific antibodies. A decrease of α4β2- and α7-nAChRs accompanied with an increase of α4β4-nAChRs in brain membranes of immunized mice was observed. Both α4(1-2...
Alzheimer\u27s disease (AD) is the most common form of brain dementia characterized by the accumulat...
International audienceKeywords: In vivo amyloid pathology Amyloid precursor protein a7 nicotinic rec...
Ph.D. University of Hawaii at Manoa 2013.Includes bibliographical references.Alzheimer's disease is ...
International audienceNicotinic acetylcholine receptors (nAChRs) of α4β2 and α7 subtypes expressed i...
Nicotinic acetylcholine receptors (nAChRs) expressed in the brain are involved in regulating cogniti...
International audienceWe examined α7β2-nicotinic acetylcholine receptor (α7β2-nAChR) expression in m...
We examined \u3b17\u3b22-nicotinic acetylcholine receptor (\u3b17\u3b22-nAChR) expression in mammali...
Abstract Background β-amyloid (Aβ) accumulation is described as a hallmark of Alzheimer’s disease (A...
We examined α7β2-nicotinic acetylcholine receptor (α7β2-nAChR) expression in mammalian brain and...
Nicotinic acetylcholine receptors (nAChRs) containing α7 subunits are thought to assemble as homome...
International audienceNicotinic acetylcholine receptors play important roles in numerous cognitive p...
Pharmacological activation of nicotinic acetylcholine receptors (nAChRs) exerts neuroprotective effe...
AbstractAlthough beta-amyloid (Aβ) has been regarded as the principal toxic factor in the pathogenes...
The nicotinic receptors (nAChRs), which play a critical role in cognitive function, are impaired ear...
The amyloid hypothesis is one of the leading theories in the search for the cause of Alzheimer's dis...
Alzheimer\u27s disease (AD) is the most common form of brain dementia characterized by the accumulat...
International audienceKeywords: In vivo amyloid pathology Amyloid precursor protein a7 nicotinic rec...
Ph.D. University of Hawaii at Manoa 2013.Includes bibliographical references.Alzheimer's disease is ...
International audienceNicotinic acetylcholine receptors (nAChRs) of α4β2 and α7 subtypes expressed i...
Nicotinic acetylcholine receptors (nAChRs) expressed in the brain are involved in regulating cogniti...
International audienceWe examined α7β2-nicotinic acetylcholine receptor (α7β2-nAChR) expression in m...
We examined \u3b17\u3b22-nicotinic acetylcholine receptor (\u3b17\u3b22-nAChR) expression in mammali...
Abstract Background β-amyloid (Aβ) accumulation is described as a hallmark of Alzheimer’s disease (A...
We examined α7β2-nicotinic acetylcholine receptor (α7β2-nAChR) expression in mammalian brain and...
Nicotinic acetylcholine receptors (nAChRs) containing α7 subunits are thought to assemble as homome...
International audienceNicotinic acetylcholine receptors play important roles in numerous cognitive p...
Pharmacological activation of nicotinic acetylcholine receptors (nAChRs) exerts neuroprotective effe...
AbstractAlthough beta-amyloid (Aβ) has been regarded as the principal toxic factor in the pathogenes...
The nicotinic receptors (nAChRs), which play a critical role in cognitive function, are impaired ear...
The amyloid hypothesis is one of the leading theories in the search for the cause of Alzheimer's dis...
Alzheimer\u27s disease (AD) is the most common form of brain dementia characterized by the accumulat...
International audienceKeywords: In vivo amyloid pathology Amyloid precursor protein a7 nicotinic rec...
Ph.D. University of Hawaii at Manoa 2013.Includes bibliographical references.Alzheimer's disease is ...