Patients with the primary immunodeficiency X-linked lymphoproliferative disease (XLP), which is caused by mutations in SH2D1A, are highly susceptible to Epstein-Barr virus (EBV) infection. Nonetheless, some XLP patients demonstrate less severe clinical manifestations after primary infection. SH2D1A encodes the adaptor molecule SLAM-associated protein (SAP), which is expressed in T and natural killer cells and is required for cytotoxicity against B cells, the reservoir for EBV. It is not known why the clinical presentation of XLP is so variable. In this study, we report for the first time the occurrence of somatic reversion in XLP. Reverted SAP-expressing cells resided exclusively within the CD8+ T cell subset, displayed a CD45RA−CCR7− effec...
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D...
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D...
X-linked lymphoproliferative disease (XLP) is a fatal immunodeficiency syndrome characterized by ful...
X-linked lymphoproliferative disease (XLP) is a condition associated with mutations in the signaling...
X-linked lymphoproliferative disease (XLP) is a condition associated with mutations in the signaling...
International audienceX-linked lymphoproliferative disease (XLP) is a condition associated with muta...
International audienceX-linked lymphoproliferative disease (XLP) is a condition associated with muta...
International audienceX-linked lymphoproliferative disease (XLP) is a condition associated with muta...
International audienceX-linked lymphoproliferative disease (XLP) is a condition associated with muta...
International audienceX-linked lymphoproliferative disease (XLP) is a condition associated with muta...
International audienceX-linked lymphoproliferative disease (XLP) is a condition associated with muta...
International audienceX-linked lymphoproliferative disease (XLP) is a condition associated with muta...
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D...
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D...
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D...
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D...
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D...
X-linked lymphoproliferative disease (XLP) is a fatal immunodeficiency syndrome characterized by ful...
X-linked lymphoproliferative disease (XLP) is a condition associated with mutations in the signaling...
X-linked lymphoproliferative disease (XLP) is a condition associated with mutations in the signaling...
International audienceX-linked lymphoproliferative disease (XLP) is a condition associated with muta...
International audienceX-linked lymphoproliferative disease (XLP) is a condition associated with muta...
International audienceX-linked lymphoproliferative disease (XLP) is a condition associated with muta...
International audienceX-linked lymphoproliferative disease (XLP) is a condition associated with muta...
International audienceX-linked lymphoproliferative disease (XLP) is a condition associated with muta...
International audienceX-linked lymphoproliferative disease (XLP) is a condition associated with muta...
International audienceX-linked lymphoproliferative disease (XLP) is a condition associated with muta...
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D...
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D...
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D...
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D...
X-linked lymphoproliferative disease (XLP) is a primary immunodeficiency caused by mutations in SH2D...
X-linked lymphoproliferative disease (XLP) is a fatal immunodeficiency syndrome characterized by ful...