During organogenesis, cell fate specification and patterning are regulated by signaling centers, specialized clusters of morphogen-expressing cells. In many organs, initiation of development is marked by bud formation, but the cellular mechanisms involved are ill defined. Here, we use the mouse incisor tooth as a model to study budding morphogenesis. We show that a group of nonproliferative epithelial cells emerges in the early tooth primordium and identify these cells as a signaling center. Confocal live imaging of tissue explants revealed that although these cells reorganize dynamically, they do not reenter the cell cycle or contribute to the growing tooth bud. Instead, budding is driven by proliferation of the neighboring cells. We demon...
When patterns are set during embryogenesis, it is expected that they are straightly established rath...
Understanding cell types and mechanisms of dental growth is essential for reconstruction and enginee...
The developing tooth offers a model for the study of ectodermal appendage organogenesis. The signali...
Signaling centers, or organizers, regulate many aspects of embryonic morphogenesis. In the mammalian...
An important event in organogenesis is the formation of signaling centers, which are clusters of gro...
During the formation of repetitive ectodermally derived organs such as mammary glands, lateral line ...
During embryogenesis, ectodermal stem cells adopt different fates and form diverse ectodermal organs...
SummaryDuring embryogenesis, ectodermal stem cells adopt different fates and form diverse ectodermal...
Specialized signaling centers act as organizers of embryonic morphogenesis. In the mammalian molar t...
AbstractEpithelial–mesenchymal interactions govern the development of epidermal organs such as teeth...
Epithelial stem cells reside in specific niches that regulate their self-renewal and differentiation...
International audienceWhen patterns are set during embryogenesis, it is expected that they are strai...
When patterns are set during embryogenesis, it is expected that they are straightly established rath...
SummaryThe proper positioning of organs during development is essential, yet little is known about t...
Teeth are vertebrate organs that arise from complex and progressive interactions between an ectoderm...
When patterns are set during embryogenesis, it is expected that they are straightly established rath...
Understanding cell types and mechanisms of dental growth is essential for reconstruction and enginee...
The developing tooth offers a model for the study of ectodermal appendage organogenesis. The signali...
Signaling centers, or organizers, regulate many aspects of embryonic morphogenesis. In the mammalian...
An important event in organogenesis is the formation of signaling centers, which are clusters of gro...
During the formation of repetitive ectodermally derived organs such as mammary glands, lateral line ...
During embryogenesis, ectodermal stem cells adopt different fates and form diverse ectodermal organs...
SummaryDuring embryogenesis, ectodermal stem cells adopt different fates and form diverse ectodermal...
Specialized signaling centers act as organizers of embryonic morphogenesis. In the mammalian molar t...
AbstractEpithelial–mesenchymal interactions govern the development of epidermal organs such as teeth...
Epithelial stem cells reside in specific niches that regulate their self-renewal and differentiation...
International audienceWhen patterns are set during embryogenesis, it is expected that they are strai...
When patterns are set during embryogenesis, it is expected that they are straightly established rath...
SummaryThe proper positioning of organs during development is essential, yet little is known about t...
Teeth are vertebrate organs that arise from complex and progressive interactions between an ectoderm...
When patterns are set during embryogenesis, it is expected that they are straightly established rath...
Understanding cell types and mechanisms of dental growth is essential for reconstruction and enginee...
The developing tooth offers a model for the study of ectodermal appendage organogenesis. The signali...