Add to ORKGOvarian cancer is the 6th most frequent and the most lethal of the gynaecological cancer; is its oestrogen dependent and it is associated with mutations in BRCA1 and BRCA2 genes. Both oestrogens and progesterone, and BRCA1 gene have important roles in the regulation of telomerase and telomeres, key structures in development and in progress in every epithelial cancer
Germline mutations in BRCA2 increase the risk of breast and ovarian cancer. The BRCA2 protein is inv...
Telomeres cap chromosome ends, protecting them from degradation, double-strand breaks, and end-to-en...
International audienceWomen’s fertility is characterized both quantitatively and qualitatively mainl...
Indiana University-Purdue University Indianapolis (IUPUI)Telomere maintenance is a critical componen...
Genetic instability plays an important role in ovarian carcinogenesis. Genetic instability is one of...
Ovarian cancer is the leading cause of gynecological cancer death in the United States. Even though ...
Objective: To compare the expression of telomerase in benign ovarian tumors and borderline ovarian t...
Background Telomeres protect chromosomal ends, shorten with cellular division, and signal cellular ...
Telomere dysfunction has been strongly implicated in the initiation of genomic instability and is su...
A study was undertaken to correlate telomere dysfunction and genomic instability with the histopatho...
Telomeres at the termini of human chromosomes are shortened with each round of cell division due to ...
Aims The aim of this study was to explore the correlation of hTERT splice variant expression with M...
BRCA1/2 are tumor suppressor genes controlling genomic stability also at telomeric and subtelomeric ...
Objective: The aim of this study was to evaluate the clinicopahtological significance of telomerase ...
In chapter 1 an overview of the content of the thesis is given. In chapter 2 current data on telomer...
Germline mutations in BRCA2 increase the risk of breast and ovarian cancer. The BRCA2 protein is inv...
Telomeres cap chromosome ends, protecting them from degradation, double-strand breaks, and end-to-en...
International audienceWomen’s fertility is characterized both quantitatively and qualitatively mainl...
Indiana University-Purdue University Indianapolis (IUPUI)Telomere maintenance is a critical componen...
Genetic instability plays an important role in ovarian carcinogenesis. Genetic instability is one of...
Ovarian cancer is the leading cause of gynecological cancer death in the United States. Even though ...
Objective: To compare the expression of telomerase in benign ovarian tumors and borderline ovarian t...
Background Telomeres protect chromosomal ends, shorten with cellular division, and signal cellular ...
Telomere dysfunction has been strongly implicated in the initiation of genomic instability and is su...
A study was undertaken to correlate telomere dysfunction and genomic instability with the histopatho...
Telomeres at the termini of human chromosomes are shortened with each round of cell division due to ...
Aims The aim of this study was to explore the correlation of hTERT splice variant expression with M...
BRCA1/2 are tumor suppressor genes controlling genomic stability also at telomeric and subtelomeric ...
Objective: The aim of this study was to evaluate the clinicopahtological significance of telomerase ...
In chapter 1 an overview of the content of the thesis is given. In chapter 2 current data on telomer...
Germline mutations in BRCA2 increase the risk of breast and ovarian cancer. The BRCA2 protein is inv...
Telomeres cap chromosome ends, protecting them from degradation, double-strand breaks, and end-to-en...
International audienceWomen’s fertility is characterized both quantitatively and qualitatively mainl...