MDM4 polymorphisms associated with and increased risk of acute lymphoblastic leukaekmia [i.e. leukemia] in Caucasian populations

Acute lymphoblastic leukemia (ALL) is a well-known malignant disorder affecting both children and adults. Althouhg the therapeutic limits have been maximized and optimized greatly, a better understanding of ALL is required for further improvements as prognostic value and cancer risk, to name a few. The genetic background has been revealed as critical to further improve the prognosis and diagnosis of ALL and other multiple malignant disorders. Hence this project proposes to study the individual genetic polymorphisms in Mdm4, a downstream gene in the P53 pathway in order to determine the susceptibility to this affection in the Caucasain population in Barcelona, Spain