Backgrounds: The Women's Health Initiative Memory Study Magnetic Resonance Imaging (WHIMS-MRI) provides an opportunity to evaluate how menopausal hormone therapy (HT) affects the structure of older women's brains. Our earlier work based on region of interest (ROI) analysis demonstrated potential structural changes underlying adverse effects of HT on cognition. However, the ROI-based analysis is limited in statistical power and precision, and cannot provide fine-grained mapping of whole-brain changes. Methods: We aimed to identify local structural differences between HT and placebo groups from WHIMS-MRI in a whole-brain refined level, by using a novel method, named Optimally-Discriminative Voxel-Based Analysis (ODVBA). ODVBA is a recently pr...
Purpose To clarify age-related structural changes specific to hippocampal volume by hierarchizing ac...
International audienceClinical data have been equivocal and controversial as to the benefits to the ...
International audienceThe menopause transition arises mainly from a decline in ovarian function char...
Backgrounds The Women's Health Initiative Memory Study Magnetic Resonance Imaging (WHIMS-MRI) provid...
OBJECTIVES: To determine whether menopausal hormone therapy (HT) affects regional brain volumes, inc...
Objectives: To determine whether menopausal hormone therapy (HT) affects regional brain vol-umes, in...
The menopausal transition has been proposed to put women at risk for undesirable neurological sympto...
<div><p></p><p>The objective of this study was to examine the effects of estrogen-based hormone ther...
The objective of this study was to examine the effects of estrogen-based hormone therapy (HT) on reg...
The hippocampus and surrounding medial temporal lobe (MTL) are critical for memory processes, with l...
Determining the benefits and/or drawbacks of hormone replacement therapy (HRT) on women’s health is ...
Objective: Menopause is associated with increasing cognitive complaints and older women are at inc...
Recently, new findings allow us to suggest that lifelong exposure to endogenous estrogens could be a...
Objective Previous studies suggest that estrogen therapy (ET) either improves or has a neutral effec...
Estrogens are known to be protective in age-associated cognitive changes in humans and in neurodegen...
Purpose To clarify age-related structural changes specific to hippocampal volume by hierarchizing ac...
International audienceClinical data have been equivocal and controversial as to the benefits to the ...
International audienceThe menopause transition arises mainly from a decline in ovarian function char...
Backgrounds The Women's Health Initiative Memory Study Magnetic Resonance Imaging (WHIMS-MRI) provid...
OBJECTIVES: To determine whether menopausal hormone therapy (HT) affects regional brain volumes, inc...
Objectives: To determine whether menopausal hormone therapy (HT) affects regional brain vol-umes, in...
The menopausal transition has been proposed to put women at risk for undesirable neurological sympto...
<div><p></p><p>The objective of this study was to examine the effects of estrogen-based hormone ther...
The objective of this study was to examine the effects of estrogen-based hormone therapy (HT) on reg...
The hippocampus and surrounding medial temporal lobe (MTL) are critical for memory processes, with l...
Determining the benefits and/or drawbacks of hormone replacement therapy (HRT) on women’s health is ...
Objective: Menopause is associated with increasing cognitive complaints and older women are at inc...
Recently, new findings allow us to suggest that lifelong exposure to endogenous estrogens could be a...
Objective Previous studies suggest that estrogen therapy (ET) either improves or has a neutral effec...
Estrogens are known to be protective in age-associated cognitive changes in humans and in neurodegen...
Purpose To clarify age-related structural changes specific to hippocampal volume by hierarchizing ac...
International audienceClinical data have been equivocal and controversial as to the benefits to the ...
International audienceThe menopause transition arises mainly from a decline in ovarian function char...