Add to ORKGIn previous studies, 56 novel selenoesters and one cyclic selenoanhydride with chemopreventive, antiproliferative and cytotoxic activity were described. Herein, the selenoanhydride and selected selenoesters were evaluated for their ability to reverse the cancer multidrug resistance (MDR) using the ABCB1 efflux pump inhibition assay in mouse MDR T-lymphoma cells. Results showed that the selenoanhydride (1) and the selenoesters with ketone terminal fragments (9-11) exerted (1.7-3.6)-fold stronger efflux pump inhibitory action than the reference verapamil. In addition, those four derivatives triggered apoptotic events in more than 80% of the examined MDR mouse cells
BACKGROUND/AIM: Multidrug resistance leads to therapeutic difficulties. There is great interest in ...
Disturbing cancer statistics, especially for breast cancer, are becoming a rationale for the develop...
The public perception of selenium has changed significantly over the last decades. Originally mainly...
In previous studies, 56 novel selenoesters and one cyclic selenoanhydride with chemopreventive, anti...
Taking into account that multidrug resistance (MDR) is the main cause for chemotherapeutic failure i...
Recently, selenium containing derivatives have attracted more attention in medicinal chemistry. In t...
Multidrug resistance (MDR) in cancer cells is a crucial aspect to consider for a successful cancer t...
Prior studies have reported the potent and selective cytotoxic, pro-apoptotic, and chemopreventive a...
Malignant diseases present a serious public health burden and their treatment with traditional chemo...
Malignant diseases present a serious public health burden and their treatment with traditional chemo...
Background/Aim: Selenium-containing compounds are becoming new alternatives in experimental chemothe...
Malignant diseases present a serious public health burden and their treatment with traditional chemo...
Fifteen selenocompounds, comprising of eight ketone-containing selenoesters (K1–K8, also known as ox...
Bacterial multidrug resistance is becoming a growing problem for public health, due to the developm...
BACKGROUND/AIM: Multidrug resistance leads to therapeutic difficulties. There is great interest in ...
BACKGROUND/AIM: Multidrug resistance leads to therapeutic difficulties. There is great interest in ...
Disturbing cancer statistics, especially for breast cancer, are becoming a rationale for the develop...
The public perception of selenium has changed significantly over the last decades. Originally mainly...
In previous studies, 56 novel selenoesters and one cyclic selenoanhydride with chemopreventive, anti...
Taking into account that multidrug resistance (MDR) is the main cause for chemotherapeutic failure i...
Recently, selenium containing derivatives have attracted more attention in medicinal chemistry. In t...
Multidrug resistance (MDR) in cancer cells is a crucial aspect to consider for a successful cancer t...
Prior studies have reported the potent and selective cytotoxic, pro-apoptotic, and chemopreventive a...
Malignant diseases present a serious public health burden and their treatment with traditional chemo...
Malignant diseases present a serious public health burden and their treatment with traditional chemo...
Background/Aim: Selenium-containing compounds are becoming new alternatives in experimental chemothe...
Malignant diseases present a serious public health burden and their treatment with traditional chemo...
Fifteen selenocompounds, comprising of eight ketone-containing selenoesters (K1–K8, also known as ox...
Bacterial multidrug resistance is becoming a growing problem for public health, due to the developm...
BACKGROUND/AIM: Multidrug resistance leads to therapeutic difficulties. There is great interest in ...
BACKGROUND/AIM: Multidrug resistance leads to therapeutic difficulties. There is great interest in ...
Disturbing cancer statistics, especially for breast cancer, are becoming a rationale for the develop...
The public perception of selenium has changed significantly over the last decades. Originally mainly...