This thesis provides an investigation of the effects of trade, technology and natural resource shocks on local economies and local labor markets. In the first chapter, I explore theoretically the impact of recent improvements in communication technology on the configuration of economic geography at multiple levels of spatial disaggregation. I show that a simple model of the organization of global supply chains can rationalize several salient stylized facts concerning the recent evolution of the spatial economy. In the second chapter, I empirically investigate the impact of changes in US trade policy triggered by China’s WTO accession on Chinese local economies. I find that improvements in US market access had an important impact on local ec...