Optimasi Formula Tablet Kunyah Dimenhidrinat Kombinasi Pengisi Manitol-Laktosa dengan Metode Simplex Lattice Design

Dimenhidrinat is an antiemetic drug which has bitter taste. Chewable tablets are some of preparation that intended for fast release. The aim of this research was to aptimized combination of Manitol-lactose as filler in making chewable tablets by applying simplex lattice design. Adsorbic mass was got by dissolved it in ethanol 70% as solvent and evaporated it on the waterbath with air flow aim until 1/10 first volume, added with lactose dried on 60 ºC. Some procedures was undertaken to get optimum mixture of Mannitol-Lactose; Formula III 100% Lactose. Tablets were made by using wet granulation method with gelatin solutipns 10% as binding agent. The granules mass obtained were sieved through 12 Mesh, dried on 50 ºC. The dried granules obtained were sieved through 16/30 Mesh. Granules obtained were tested for physical characteristic including tapping index, granule density, water absorption capacity and compactibility. The total respond of some properties values was calculated to get optimum formula. Granules of optimum formula were compressed using single punch machine tablet by keeping the force constant. Tablets that produce from optimum formula were tested for physical characteristic including uniformity of weight, hardness, and disintegration time. The data obtained of granules testing were analyzed with T-test using 95% signification level. The result showed for optimum formula (90% Mannitol : 10% Lactose) had good physical characteristic of granules (tapping index 14,80%; granule density 0,5352 g/ml, water absorption capacity 0,1536 g/minute; compacibility 7,42 kg). The result of physical characteristic test of tablets consist of (uniformity of weight 499,85 mg with CV 0,396%; hardness 7,60 kg; fragility 0,149%; disintegration time 13,60 minute). The taste test yablets showed that almost 100% of the respondent mentioned that chewable tablets dimenhidrinat still bitter. Keywords: Dimenhidrinat, mannitol, Lactose, Simplex Lattice Desig