The goal of this study is to demonstrate an alternative procedure to perform topical photodynamic therapy (PDT). Here, we propose the combined use of negative pressure and a 5-Aminolevulinic acid (5-ALA) cream occlusion to increase protoporphyrin IX (PPIX) formation. Background data: PDT using topical 5-ALA as a prodrug and precursor of PPIX has been used in the treatment and diagnosis of different types of cancer and skin diseases. The use of 5-ALA offers many advantages as a localized and non-systemic application, but it shows limitations in relation to skin penetration. Many authors have discussed the limitations of 5-ALA penetration through the skin. The skin penetration of 5-ALA can be optimized using mechanical devices associated with...
Journal Article“The final publication is available at Springer via http://dx.doi.org/10.1007/s10103-...
This article provides an update on photodynamic therapy by discussing each of the essential componen...
Author's post-print is subject to a Creative Commons Attribution Non-Commercial No Derivatives Licen...
AbstractPhotodynamic therapy (PDT) is a popular technique for skin cancer treatment. Protoporphyrin ...
Most existing theoretical models of photodynamic therapy (PDT) assume a uniform initial distribution...
International audiencePhotodynamic therapy (PDT) induced by protoporphyrin IX (PpIX) has been widely...
Funding: EPSRC EP/J01771X, Royal Society Wolfson Research Merit AwardBackground Topical Photodynamic...
Protoporphyrin IX (PpIX)-induced photodynamic therapy (POT) utilises the combined interaction of the...
Photodynamic therapy (PDT) is a promising treatment strategy for malignant and nonmalignant lesions....
The success reported for the treatment of superficial skin carcinomas by photodynamic therapy with t...
PublishedArticle© Under License of Creative Commons Attribution 3.0 LicenseProtoporphyrin IX (PpIX)-...
Item does not contain fulltextThe response rates of photodynamic therapy (PDT) vary widely. Limited ...
This is the final version. Available on open access from Elsevier via the DOI in this recordBackgrou...
Photodynamic Therapy (PDT) with 5-aminolevulinic acid (ALA) is known to be limited for applications ...
One of the limitations of topical photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) is th...
Journal Article“The final publication is available at Springer via http://dx.doi.org/10.1007/s10103-...
This article provides an update on photodynamic therapy by discussing each of the essential componen...
Author's post-print is subject to a Creative Commons Attribution Non-Commercial No Derivatives Licen...
AbstractPhotodynamic therapy (PDT) is a popular technique for skin cancer treatment. Protoporphyrin ...
Most existing theoretical models of photodynamic therapy (PDT) assume a uniform initial distribution...
International audiencePhotodynamic therapy (PDT) induced by protoporphyrin IX (PpIX) has been widely...
Funding: EPSRC EP/J01771X, Royal Society Wolfson Research Merit AwardBackground Topical Photodynamic...
Protoporphyrin IX (PpIX)-induced photodynamic therapy (POT) utilises the combined interaction of the...
Photodynamic therapy (PDT) is a promising treatment strategy for malignant and nonmalignant lesions....
The success reported for the treatment of superficial skin carcinomas by photodynamic therapy with t...
PublishedArticle© Under License of Creative Commons Attribution 3.0 LicenseProtoporphyrin IX (PpIX)-...
Item does not contain fulltextThe response rates of photodynamic therapy (PDT) vary widely. Limited ...
This is the final version. Available on open access from Elsevier via the DOI in this recordBackgrou...
Photodynamic Therapy (PDT) with 5-aminolevulinic acid (ALA) is known to be limited for applications ...
One of the limitations of topical photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA) is th...
Journal Article“The final publication is available at Springer via http://dx.doi.org/10.1007/s10103-...
This article provides an update on photodynamic therapy by discussing each of the essential componen...
Author's post-print is subject to a Creative Commons Attribution Non-Commercial No Derivatives Licen...