Accessory spleen versus lymph node: Value of iodine quantification with dual-energy computed tomography

OBJECTIVES: To evaluate whether iodine quantification with Dual-Energy Computed Tomography (DECT) improves the differentiation of accessory spleens (AS) from lymph nodes (LN) compared to CT number measurements. METHODS: Abdominal DECT images of 75 patients with either AS (n=35) or LN (n=48) (benign entity) were retrospectively evaluated. Hounsfield Units (HU) and iodine concentrations of AS, LN and the main spleen were measured. Receiver operating characteristics (ROC) were performed to calculate an optimal threshold for distinguishing AS from LN. Sensitivity, specificity, and accuracy were calculated for distinguishing AS from LN by iodine concentration measurements. RESULTS: Mean CT numbers and iodine concentrations were higher for AS (148±29 HU and 48.2±11×100μg/cc) than LN (83±19 HU and 31.5±6.2×100μg/cc, respectively, P<0.001 each). Mean CT numbers were lower for AS compared to the main spleen (161±29HU, P