Background - Streptococcus agalactiae can cause urinary tract infection (UTI). The role of the S. agalactiae global virulence regulator, CovR, in UTI pathogenesis is unknown Methods - We used murine and human bladder uroepithelial cell models of UTI and S. agalactiae mutants in covR and related factors, including -hemolysin/cytolysin ( -h/c), surface-anchored adhesin HvgA, and capsule to study the role of CovR in UTI. Results - covR-deficient serotype III S. agalactiae 874391 was significantly attenuated for colonization in mice and adhesion to uroepithelial cells. Mice infected with covR-deficient S. agalactiae produced less pro-inflammatory cytokines compared to wild type (WT) 874391. Acute cytotoxicity in uroepithelial cells triggered by...
S. agalactiae (group B streptococci, GBS) is a major microbial pathogen in human neonates and causes...
International audienceAbstract : Streptococcus agalactiae is a leading cause of infections in neonat...
A recurrent urinary tract infection (UTI) is a common debilitating condition whereby uropathogens ar...
Background. Streptococcus agalactiae can cause urinary tract infection (UTI). The role of the S. aga...
Group B Streptococcus (GBS; Streptococcus agalactiae) is a major human pathogen that disproportionat...
Group B Streptococcus (GBS; Streptococcus agalactiae) is a major human pathogen that disproportionat...
Group B Streptococcus (GBS; Streptococcus agalactiae) is a major human pathogen that disproportionat...
International audienceIn this study, we carried out a detailed structural and functional analysis of...
Group B Streptococcus (GBS) causes urinary tract infections, but the pathogenic mechanisms underlyin...
Staphylococcus saprophyticus, an obligate human pathogen, is the most common Gram-positive causative...
The most common causes of urinary tract infections (UTIs) are Gram-negative pathogens such as Escher...
CodY is a highly conserved global transcriptional regulator of metabolism in low-G+C Gram-positive b...
Group B Streptococcus (GBS) causes urinary tract infections, but the pathogenic mechanisms underlyin...
Streptococcus agalactiae causes urinary tract infection (UTI) in pregnant adults, non-pregnant adult...
Streptococcus agalactiae is the leading cause of bacterial sepsis and meningitis in neonates and als...
S. agalactiae (group B streptococci, GBS) is a major microbial pathogen in human neonates and causes...
International audienceAbstract : Streptococcus agalactiae is a leading cause of infections in neonat...
A recurrent urinary tract infection (UTI) is a common debilitating condition whereby uropathogens ar...
Background. Streptococcus agalactiae can cause urinary tract infection (UTI). The role of the S. aga...
Group B Streptococcus (GBS; Streptococcus agalactiae) is a major human pathogen that disproportionat...
Group B Streptococcus (GBS; Streptococcus agalactiae) is a major human pathogen that disproportionat...
Group B Streptococcus (GBS; Streptococcus agalactiae) is a major human pathogen that disproportionat...
International audienceIn this study, we carried out a detailed structural and functional analysis of...
Group B Streptococcus (GBS) causes urinary tract infections, but the pathogenic mechanisms underlyin...
Staphylococcus saprophyticus, an obligate human pathogen, is the most common Gram-positive causative...
The most common causes of urinary tract infections (UTIs) are Gram-negative pathogens such as Escher...
CodY is a highly conserved global transcriptional regulator of metabolism in low-G+C Gram-positive b...
Group B Streptococcus (GBS) causes urinary tract infections, but the pathogenic mechanisms underlyin...
Streptococcus agalactiae causes urinary tract infection (UTI) in pregnant adults, non-pregnant adult...
Streptococcus agalactiae is the leading cause of bacterial sepsis and meningitis in neonates and als...
S. agalactiae (group B streptococci, GBS) is a major microbial pathogen in human neonates and causes...
International audienceAbstract : Streptococcus agalactiae is a leading cause of infections in neonat...
A recurrent urinary tract infection (UTI) is a common debilitating condition whereby uropathogens ar...