While it is widely known that alcohol and nicotine addictions commonly co-occur, no pharmacotherapies are yet marketed for codependent individuals. This is a striking observation given the broad implications and detrimental impacts that arise from this drug combination. Over the past decade, clinical and research efforts have exposed a common effector-neuronal nicotinic acetylcholine receptors (nAChRs). In this chapter, we describe alcohol's actions as a powerful reinforcer. Through neuronal nAChRs, alcohol hijacks the natural reward circuitry and creates conditioned drug associations. This endows it with the power to sustain, prolong, and reinstate further alcohol and nicotine-seeking behaviors. The narrative is based on experience and con...
Alcohol and nicotine dependence are the most serious public health problems worldwide in terms of he...
Alcohol and nicotine use are both highly prevalent in the United States. It is estimated that over 1...
Addictive drugs can activate systems involved in normal reward-related learning, creating long-lasti...
Neuronal nicotinic acetylcholine receptors are important targets for alcohol reward and dependence. ...
Background The frequent co-abuse of alcohol and tobacco may suggest that they share some common neur...
Alcohol use disorders (AUDs) are complex and developing effective treatments will require the combin...
Owing to the substantial comorbidity of nicotine and alcohol, this project was designed to explore t...
International audienceAlcohol and nicotine are the most widely co-abused drugs. Both modify the acti...
Alcohol and nicotine are often co-abused. As many as 80-95% of alcoholics are also smokers, suggesti...
The mesolimbic dopamine system is believed to mediate the positive reinforcing and rewarding effects...
Alcohol is the most commonly abused legal substance and alcoholism is a serious public health proble...
Background and Purpose: Alcohol and nicotine use disorders are commonly comorbid. Both alcohol and n...
Both smoking and alcohol consumption are known to cause severe health problems and there is an exten...
Alcohol (ethanol) and smoking (nicotine) are commonly co-abused in human beings. Drugs of abuse inte...
Background and Purpose: Alcohol and nicotine use disorders are commonly comorbid. Both alcohol and n...
Alcohol and nicotine dependence are the most serious public health problems worldwide in terms of he...
Alcohol and nicotine use are both highly prevalent in the United States. It is estimated that over 1...
Addictive drugs can activate systems involved in normal reward-related learning, creating long-lasti...
Neuronal nicotinic acetylcholine receptors are important targets for alcohol reward and dependence. ...
Background The frequent co-abuse of alcohol and tobacco may suggest that they share some common neur...
Alcohol use disorders (AUDs) are complex and developing effective treatments will require the combin...
Owing to the substantial comorbidity of nicotine and alcohol, this project was designed to explore t...
International audienceAlcohol and nicotine are the most widely co-abused drugs. Both modify the acti...
Alcohol and nicotine are often co-abused. As many as 80-95% of alcoholics are also smokers, suggesti...
The mesolimbic dopamine system is believed to mediate the positive reinforcing and rewarding effects...
Alcohol is the most commonly abused legal substance and alcoholism is a serious public health proble...
Background and Purpose: Alcohol and nicotine use disorders are commonly comorbid. Both alcohol and n...
Both smoking and alcohol consumption are known to cause severe health problems and there is an exten...
Alcohol (ethanol) and smoking (nicotine) are commonly co-abused in human beings. Drugs of abuse inte...
Background and Purpose: Alcohol and nicotine use disorders are commonly comorbid. Both alcohol and n...
Alcohol and nicotine dependence are the most serious public health problems worldwide in terms of he...
Alcohol and nicotine use are both highly prevalent in the United States. It is estimated that over 1...
Addictive drugs can activate systems involved in normal reward-related learning, creating long-lasti...