Background & Aims Trefoil factors (TFFs) regulate mucosal repair and suppress tumor formation in the stomach. Tff1 deficiency results in gastric cancer, whereas Tff2 deficiency increases gastric inflammation. TFF2 expression is frequently lost in gastric neoplasms, but the nature of the silencing mechanism and associated impact on tumorigenesis have not been determined. Methods We investigated the epigenetic silencing of TFF2 in gastric biopsy specimens from individuals with Helicobacter pylori-positive gastritis, intestinal metaplasia, gastric cancer, and disease-free controls. TFF2 function and methylation were manipulated in gastric cancer cell lines. The effects of Tff2 deficiency on tumor growth were investigated in the gp130[supers...
Abstract Background Epstein-Barr Virus (EBV) is found in 10% of all gastric adenocarcinomas but its ...
: Chronic Helicobacter pylori infection is the leading cause of intestinal-type adenocarcinoma, as p...
Purpose: Promoter hypermethylation of E-cadherin plays an important role on gastric cancer developme...
Background & Aims Trefoil factors (TFFs) regulate mucosal repair and suppress tumor formation in...
Trefoil factor 1 (TFF1, also known as pS2) is strongly expressed in the gastrointestinal mucosa and ...
International audienceHelicobacter pylori infection is associated with the development of gastric ad...
Helicobacter pylori and Epstein-Barr virus (EBV) are two well-known contributors to cancer and can e...
Gastric cancer is the fourth most common cancer and the second leading cause of cancer death worldwi...
Using in vitro and in vivo models, we investigated the role of TFF1 in suppressing H. pylori-mediate...
The loss-of-function variants are thought to be associated with inflammation in the stomach. We here...
Abstract MTHFR C677T and Helicobacter pylori infec- tion are believed to play critical roles in...
Artículo de publicación ISIThe sequence of events associated with the development of gastric cancer ...
International audienceBackground: GATA factors, which constitute a family of transcription regulator...
Background/Aims Gastrointestinal glandular stem cells renew every 8 years. New stem cells with imped...
Epigenetics regulates gene expression, cell type development during differentiation, and the cell re...
Abstract Background Epstein-Barr Virus (EBV) is found in 10% of all gastric adenocarcinomas but its ...
: Chronic Helicobacter pylori infection is the leading cause of intestinal-type adenocarcinoma, as p...
Purpose: Promoter hypermethylation of E-cadherin plays an important role on gastric cancer developme...
Background & Aims Trefoil factors (TFFs) regulate mucosal repair and suppress tumor formation in...
Trefoil factor 1 (TFF1, also known as pS2) is strongly expressed in the gastrointestinal mucosa and ...
International audienceHelicobacter pylori infection is associated with the development of gastric ad...
Helicobacter pylori and Epstein-Barr virus (EBV) are two well-known contributors to cancer and can e...
Gastric cancer is the fourth most common cancer and the second leading cause of cancer death worldwi...
Using in vitro and in vivo models, we investigated the role of TFF1 in suppressing H. pylori-mediate...
The loss-of-function variants are thought to be associated with inflammation in the stomach. We here...
Abstract MTHFR C677T and Helicobacter pylori infec- tion are believed to play critical roles in...
Artículo de publicación ISIThe sequence of events associated with the development of gastric cancer ...
International audienceBackground: GATA factors, which constitute a family of transcription regulator...
Background/Aims Gastrointestinal glandular stem cells renew every 8 years. New stem cells with imped...
Epigenetics regulates gene expression, cell type development during differentiation, and the cell re...
Abstract Background Epstein-Barr Virus (EBV) is found in 10% of all gastric adenocarcinomas but its ...
: Chronic Helicobacter pylori infection is the leading cause of intestinal-type adenocarcinoma, as p...
Purpose: Promoter hypermethylation of E-cadherin plays an important role on gastric cancer developme...