Add to ORKGThesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2015.Cataloged from PDF version of thesis.Includes bibliographical references (pages [130]-140).Fluctuations in the transcriptional and proteomic state of single cells is a common feature of living systems. The focus of this work is to understand the epigenetic orgin of this heterogeneity. For biochemical noise arising from the intrinsic stochasticity of molecular interactions, we have experimentally established a microRNA mediated mechanism through which epigenetically determined rate parameters are optimized to suppress noise in protein abundance. We further explore regulated fluctuations that confer phenotypic specificty in e...
The human body is a patchwork of tissues working collectively to maintain homeostasis and achieve fi...
Cells and organisms are remarkably robust: they alter the variety and levels of expressed genes and ...
To understand the full breadth of the physiological implications of random fluctuations, of crucial ...
Cell populations can be strikingly heterogeneous, composed of multiple cellular states, each exhibit...
The self-organisation of cells into complex tissues relies on the tight regulation of molecular proc...
SummaryMethods for single-cell genome and transcriptome sequencing have contributed to our understan...
Transcriptional noise is an intrinsic feature of cell populations and plays a driving role in mammal...
Traditional gene expression studies have largely ignored cell-to-cell variability in transcription. ...
Single-cell transcriptomics has recently emerged as a powerful technology to explore gene expression...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2014.Cata...
Single-cell transcriptomics has recently emerged as a powerful technology to explore gene expression...
Methods for single-cell genome and transcriptome sequencing have contributed to our understanding of...
In this Perspective, we synthesize past and present observations in the field of epigenetics to prop...
The ability of cells to establish and remember their gene expression states is a cornerstone of mult...
Single-cell RNA sequencing is a powerful tool for exploring gene expression heterogeneity, but the r...
The human body is a patchwork of tissues working collectively to maintain homeostasis and achieve fi...
Cells and organisms are remarkably robust: they alter the variety and levels of expressed genes and ...
To understand the full breadth of the physiological implications of random fluctuations, of crucial ...
Cell populations can be strikingly heterogeneous, composed of multiple cellular states, each exhibit...
The self-organisation of cells into complex tissues relies on the tight regulation of molecular proc...
SummaryMethods for single-cell genome and transcriptome sequencing have contributed to our understan...
Transcriptional noise is an intrinsic feature of cell populations and plays a driving role in mammal...
Traditional gene expression studies have largely ignored cell-to-cell variability in transcription. ...
Single-cell transcriptomics has recently emerged as a powerful technology to explore gene expression...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2014.Cata...
Single-cell transcriptomics has recently emerged as a powerful technology to explore gene expression...
Methods for single-cell genome and transcriptome sequencing have contributed to our understanding of...
In this Perspective, we synthesize past and present observations in the field of epigenetics to prop...
The ability of cells to establish and remember their gene expression states is a cornerstone of mult...
Single-cell RNA sequencing is a powerful tool for exploring gene expression heterogeneity, but the r...
The human body is a patchwork of tissues working collectively to maintain homeostasis and achieve fi...
Cells and organisms are remarkably robust: they alter the variety and levels of expressed genes and ...
To understand the full breadth of the physiological implications of random fluctuations, of crucial ...