Engineering particle trajectories in microfluidic flows using particle shape

Recent advances in microfluidic technologies have created a demand for techniques to control the motion of flowing microparticles. Here we consider how the shape and geometric confinement of a rigid microparticle can be tailored for ‘self-steering’ under external flow. We find that an asymmetric particle, weakly confined in one direction and strongly confined in another, will align with the flow and focus to the channel centreline. Experimentally and theoretically, we isolate three viscous hydrodynamic mechanisms that contribute to particle dynamics. Through their combined effects, a particle is stably attracted to the channel centreline, effectively behaving as a damped oscillator. We demonstrate the use of self-steering particles for microfluidic device applications, eliminating the need for external forces or sheath flows.National Science Foundation (U.S.) (Grant CMMI-1120724)Novartis (Firm)United States. Army Research Office (Institute for Collaborative Biotechnologies Contract W911NF-09-D-0001