Publication date
February 2009
DOI Publisher
Elsevier BV ISSN
0092-8674 Journal
issn:1097-4172 Citation count (estimate)
575Abstract
MicroRNAs (miRNAs) may be important regulators of gene expression. By modulating oncogenic and tumor suppressor pathways they could, in principle, contribute to tumorigenesis. Consistent with this hypothesis, recurrent genetic and epigenetic alterations of individual miRNAs are found in some tumors. Functional studies are now elucidating the mechanism of action of putative oncogenic and tumor suppressor miRNAs
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