Coupling polymerization initiators to molecular recognition events provide the ability to amplify these events and detect them using the formation of a cross-linked polymer as an inexpensive readout that is visible to the unaided eye. The eosin-tertiary amine co-initiation system, activated by visible light, has proven utility in this context when an average of three eosin molecules are coupled to a protein detection reagent. The present work addresses the question of how detection sensitivity is impacted when the number of eosin molecules per binding event increases in the range of two to fifteen. Unlike in other initiation systems, a non-monotonic relationship is observed between the number of initiators per binding event and the observed...
In order to generate an efficient detection assay, an analyte’s signal must be amplified to provide ...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2016.Cata...
The ability to optically monitor a chemical reaction and generate an in situ readout is an important...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2015.Cata...
We report a systematic investigation of a set of photoreducible macrophotoinitiators for use in poly...
Photopolymerization-based signal amplification (PBA) is a method to enhance biodetection signals by ...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2016.This...
Many studies have demonstrated the concept of using free-radical polymerization reactions to provide...
Targeted photopolymerization is the basis for multiple diagnostic and cell encapsulation technologie...
In conjunction with a tertiary amine coinitiator, eosin, a photoreducible dye, has been shown to suc...
When eosin-mediated, photo-redox polymerization is used to amplify signals in biosensing, oxygen has...
Many studies have demonstrated the concept of using free-radical polymerization reactions to provide...
The initiation efficiency and the excited state dynamics of the three triplet radical photoinitiator...
The development of novel approaches to signal amplification in aqueous media could enable new diagno...
We developed a versatile DNA assay and framework for monitoring polymerization of DNA in real time ...
In order to generate an efficient detection assay, an analyte’s signal must be amplified to provide ...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2016.Cata...
The ability to optically monitor a chemical reaction and generate an in situ readout is an important...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2015.Cata...
We report a systematic investigation of a set of photoreducible macrophotoinitiators for use in poly...
Photopolymerization-based signal amplification (PBA) is a method to enhance biodetection signals by ...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2016.This...
Many studies have demonstrated the concept of using free-radical polymerization reactions to provide...
Targeted photopolymerization is the basis for multiple diagnostic and cell encapsulation technologie...
In conjunction with a tertiary amine coinitiator, eosin, a photoreducible dye, has been shown to suc...
When eosin-mediated, photo-redox polymerization is used to amplify signals in biosensing, oxygen has...
Many studies have demonstrated the concept of using free-radical polymerization reactions to provide...
The initiation efficiency and the excited state dynamics of the three triplet radical photoinitiator...
The development of novel approaches to signal amplification in aqueous media could enable new diagno...
We developed a versatile DNA assay and framework for monitoring polymerization of DNA in real time ...
In order to generate an efficient detection assay, an analyte’s signal must be amplified to provide ...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2016.Cata...
The ability to optically monitor a chemical reaction and generate an in situ readout is an important...