How neurons develop their morphology is an important question in neurobiology. Here we describe a new pathway that specifically affects the formation of basal dendrites and axonal projections in cortical pyramidal neurons. We report that thousand-and-one-amino acid 2 kinase (TAOK2), also known as TAO2, is essential for dendrite morphogenesis. TAOK2 downregulation impairs basal dendrite formation in vivo without affecting apical dendrites. Moreover, TAOK2 interacts with Neuropilin 1 (Nrp1), a receptor protein that binds the secreted guidance cue Semaphorin 3A (Sema3A). TAOK2 overexpression restores dendrite formation in cultured cortical neurons from Nrp1[superscript Sema−] mice, which express Nrp1 receptors incapable of binding Sema3A. TAOK...
Precise dendrite patterning is critical for the wiring and function of the entire nervous system. Pr...
SummaryDendrite arborization and synapse formation are essential for wiring the neural circuitry. Th...
Autism spectrum disorder (hereafter referred to as "ASD") is a heterogeneous neurodevelopmental cond...
1 0 2 2 VOLUME 15 | NUMBER 7 | JULY 2012 nature neurOSCIenCe a r t I C l e S Pyramidal neurons are a...
Dendritic arborization is highly regulated and requires tight control of dendritic growth, branching...
Abnormalities in dendritic spines are manifestations of several neurodevelopmental and psychiatric d...
Thousand and one amino acid kinase 1 (TAOK1) is a MAP3K protein kinase, regulating different mitogen...
<div><p>The architecture of dendritic arbors determines circuit connectivity, receptive fields, and ...
Mutations in GRIN2B, which encodes the GluN2B subunit of NMDA receptors, lead to autism spectrum dis...
The architecture of dendritic arbors determines circuit connectivity, receptive fields, and computat...
The architecture of dendritic arbors determines circuit connectivity, receptive fields, and computat...
© 2014 Wiley Periodicals, Inc. A number of recent reports implicate the differential regulation of a...
We identified seven families associating NEUROD2 pathogenic mutations with ASD and intellectual disa...
Phelan–McDermid syndrome (also known as 22q13.3 deletion syndrome) is a syndromic form of autism spe...
Background: The anterior cingulate cortex (ACC) is a brain area involved in modulating behavior asso...
Precise dendrite patterning is critical for the wiring and function of the entire nervous system. Pr...
SummaryDendrite arborization and synapse formation are essential for wiring the neural circuitry. Th...
Autism spectrum disorder (hereafter referred to as "ASD") is a heterogeneous neurodevelopmental cond...
1 0 2 2 VOLUME 15 | NUMBER 7 | JULY 2012 nature neurOSCIenCe a r t I C l e S Pyramidal neurons are a...
Dendritic arborization is highly regulated and requires tight control of dendritic growth, branching...
Abnormalities in dendritic spines are manifestations of several neurodevelopmental and psychiatric d...
Thousand and one amino acid kinase 1 (TAOK1) is a MAP3K protein kinase, regulating different mitogen...
<div><p>The architecture of dendritic arbors determines circuit connectivity, receptive fields, and ...
Mutations in GRIN2B, which encodes the GluN2B subunit of NMDA receptors, lead to autism spectrum dis...
The architecture of dendritic arbors determines circuit connectivity, receptive fields, and computat...
The architecture of dendritic arbors determines circuit connectivity, receptive fields, and computat...
© 2014 Wiley Periodicals, Inc. A number of recent reports implicate the differential regulation of a...
We identified seven families associating NEUROD2 pathogenic mutations with ASD and intellectual disa...
Phelan–McDermid syndrome (also known as 22q13.3 deletion syndrome) is a syndromic form of autism spe...
Background: The anterior cingulate cortex (ACC) is a brain area involved in modulating behavior asso...
Precise dendrite patterning is critical for the wiring and function of the entire nervous system. Pr...
SummaryDendrite arborization and synapse formation are essential for wiring the neural circuitry. Th...
Autism spectrum disorder (hereafter referred to as "ASD") is a heterogeneous neurodevelopmental cond...