Remodeling of ECM patch into functional myocardium in an ovine model: A pilot study
- Scully, Brandi B.
- Fan, Chris
- Grigoryan, Bagrat
- Jacot, Jeffrey G.
- Vick, G. Wesley III
- Kim, Jeffrey J.
- Fraser, Charles D.
- Grande-Allen, K. Jane
- Morales, David L.S.
DOIAbstract
Background: Previous studies have demonstrated that surgical patches comprised of small intestinal submucosa-derived extracellular matrix (ECM) have biological remodeling potential. This pilot study investigated histological, mechanical, and bioelectrical properties of an ECM patch implanted in the ovine right-ventricular outflow tract (RVOT). Materials and Methods: ECM patches (2 × 2 cm2) were implanted in four Western Range sheep (wether males, 37–49 kg, age <1 year) and explanted at 5 months (n = 2) and 8 months (n = 2). In vivo analysis included epicardial echocardiography and contact electrical mapping. Optical mapping was used to map electrical activity of two hearts on a Langendorff preparation. Mechanical testing quantified stiffnes...
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