New refrigerants with considerable low environmental impact are currently under evaluation by the refrigeration industry. Such refrigerants could be used in place of high global warming fluids like R404A. Among these new fluids are 1234ze, N-13, L-40 and N-40. Initial laboratory evaluations of these refrigerants showed good energy efficiency due to their good thermal properties. These initial evaluations were followed by larger scale (field) trials, refrigerant–oil property measurements, and also material compatibility. This study presents and discusses results of such evaluations, and extends the assessment to LCCP using different refrigeration technologies and refrigerants