Role of Tropical Cream Extract Garlic ( Allium Sativum ) in Wound Healing Fibroblasts judging form the Strain Wistar Rats with Acute Injury Models

-Wound will cause problems if handled poorly, causing chronic wounds. Garlic ( Allium sativum) is a typical plant of the tropic, including Indonesia, the tubers are often used in traditional medicine, among them to eal wound. This laboratory experimental study using randomized designs Post Test Control Group aims to determine the effect of the use of Topical Cream Extract garlic (Allium sativum) on wound healing in topical administration, with a view histopathologrc consisting of fibroblasts.This study conducted using 4 laboratories are Biofarmaka Center activity of Research (PKP) Hasanuddin University\ud to the process of making Cream Topical garlic exhact {EBP10%), Laboratory Animal Medical Faculty of Hasanuddin University for maintenance and treatment of experimental animals, Laboratory Histophatology Center for Veterinary Maros for manufacturing slide histopathology in Seplember 2015 - Febtuary 2016. the study was conducted in 54 rats by making excision ofthe left and right back diameter of 8 mm by using punc byopsi. Then\ud the mice were drvided inlo 3 goups: negative control 0.9% NaCl, Oksitetracycline positive control group and a treatment group 3% Topical Cream EBP 10%. The scar tissue of each group were observed microscopically on days 3, 7, and 14. The results showed wound healing treatment group tend to be better, sgen in the mean value and standard deviation of the number of fibroblast cells EBP 10% topical cream group on day3 (1.0+0.63),day7(1.5\ud + 0.55) and day 14 (3.0 + 0.63). Test results one way ANOVA fibroblast cell counts significantly different all groups based on the time of day 3 (p: 0.025) and day 14 (p: 0.000). Results of post hoc test showed no significant diifference in the group EBP10% tropical Cream with negative control diay 3 (p: 0.011), day 7 (P: 0.034) and day 14 (p: 0.000). In conclusion, Cream topical EBP l0%. tend to be usefull in wound healing, and statistically significant