Protective effects of daily topical cocoa extract to the expression of 8-OHdG and PCNA on UVB-exposed albino mice

-Background. Chronic impact caused by repeated exposure to low energy levels of ultraviolet B (UVB), are in the form of precancerous, skin cancer and premature aging. 8-hydroxy-2- deoxyguanosine (8-OHdG) and proliferating cell nuclear antigen (PCNA) known asbiomarker for UVB-induced DNA damage. Antioxidant arc used to protect the skin from UVB-induced DNA damage, and cocoa is one of them due to their polyphenol content Aims. Examine the protective effects of daily topical cocoa on UVB-exposed albino mice by measuring the expression of 8-OHdG (photoproduct) and PCNA. Method. 25 mice were randomly divided int