A Cu/Pd Cooperative Catalysis for Enantioselective Allylboration of Alkenes
- Jia, Tao
- Cao, Peng
- Wang, Bing
- Lou, Yazhou
- Yin, Xuemei
- Wang, Min
- Liao, Jian
- Liao, J (reprint author), Chinese Acad Sci, Nat Prod Res Ctr, Chengdu Inst Biol, Chengdu 610041, Peoples R China.
Publication date
January 2015
DOI Publisher
American Chemical Society (ACS) ISSN
0002-7863 Citation count (estimate)
57Abstract
A cooperative Cu/Pd-catalyzed asymmetric three-component reaction of styrenes, B-2(pin)(2), and allyl carbonates was reported. This reaction, in the presence of chiral CuOAc/SOP and achiral Pd(dppf)Cl-2 catalysts, occurs smoothly with high enantioselectivities (up to 97% ee). The allylboration products, which contain alkene (or diene) unite and alkylboron group, are easily functionalized. The utility of this protocol was demonstrated through the synthesis of an antipsychotic drug, (-)-predamol
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