Single molecule based SNP detection using designed DNA carriers and solid-state nanopores

Single nucleotide polymorphisms (SNPs) play a crucial role as molecular markers in medical and diagnostic application. We demonstrate a nanopore based method for SNP detection at the single molecule level. Designed DNA carriers are used to distinguish DNA strands containing only one single base difference and follow strand displacement kinetics.J. Kong acknowledges funding from Chinese Scholarship Council and Cambridge Trust. J. Zhu and UFK acknowledge support from an ERC Consolidator grant (DesignerPores 647144)