Synthèse de dihydro‐6,7‐imidazo[1,2−a]triazines‐1,3,5 disubstituées

Four 2,4‐disubstituted 6,7‐dihydro‐imidazo[1,2−a]‐s‐triazines (IV, VII, X and XV) have been synthesized according to the following scheme: (a) monosubstitution of cyanuric chloride (I) with ethanolamine, (b) replacement of the remaining chlorine atomes by suitable groupe, and (c) cyclisation of the 2′‐hydroxy‐ethylamino side chain on one of the adjacent cyclic nitrogen atoms of the s‐triazine nucleus. This last step includes reaction of the 2‐[(2‐hydroxy‐ethyl)‐amino]‐s‐triazines with thionyle chloride or p‐toluenesulfonyl chloride and, with one exception (VIII→IX), heating the resulting 2‐[(2‐chloro‐ethyl)‐amino] derivatives or p‐toluenesulfonic esters in a solvent. Copyright © 1961 Verlag GmbH & Co. KGaA, WeinheimSCOPUS: ar.jFLWNA