Add to ORKGOur understanding of the post-transcriptional modifications that decorate mRNAs, a regulatory layer positioned between DNA and proteins, is in its infancy. Recent advances in genome-wide mapping of pseudouridine (ψ), N6-methyladenosine (m6A), 5-methylcytosine (5mrC), its oxidation product 5-hydroxymethylcytosine (5hmrC), and N1-methyladenosine (m1A) have proven that these modifications unsuspectedly occur from dozens to thousands of different gene transcripts in eukaryotic cells. Therefore epigenetics cannot only be restricted to chromatin modifications, and, when studying gene regulation, one has to consider the expanding kingdom of RNA modifications, also known as the epitranscriptome.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
The broad application of next-generation sequencing technologies in conjunction with improved bioinf...
peer reviewedThe genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and...
In recent years, there has been an increase in research efforts surrounding RNA modification thanks ...
RNA contains more than 100 distinct modifications that promote the functions of stable noncoding RNA...
RNA modifications have recently emerged as an important regulatory layer of gene expression. The mos...
The first chemical modification to RNA was discovered nearly 60 years ago; to date, more than 100 ch...
Although a plethora of DNA modifications have been extensively investigated in the last decade, rece...
Sequence databases and transcriptome-wide mapping have revealed different reversible and dynamic che...
In recent years, major breakthroughs in RNA-modification-mediated regulation of gene expression have...
Sequence databases and transcriptome-wide mapping have revealed different reversible and dynamic che...
Abstract RNA contains over 150 types of chemical modifications. Although many of these chemical modi...
RNA modifications have recently emerged as a widespread and complex facet of gene expression regulat...
Innovations in epitranscriptomics have resulted in the identification of more than 160 RNA modificat...
The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Tr...
Eukaryotic cells utilize a wide range of mechanisms to regulate gene expression, generating divergen...
The broad application of next-generation sequencing technologies in conjunction with improved bioinf...
peer reviewedThe genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and...
In recent years, there has been an increase in research efforts surrounding RNA modification thanks ...
RNA contains more than 100 distinct modifications that promote the functions of stable noncoding RNA...
RNA modifications have recently emerged as an important regulatory layer of gene expression. The mos...
The first chemical modification to RNA was discovered nearly 60 years ago; to date, more than 100 ch...
Although a plethora of DNA modifications have been extensively investigated in the last decade, rece...
Sequence databases and transcriptome-wide mapping have revealed different reversible and dynamic che...
In recent years, major breakthroughs in RNA-modification-mediated regulation of gene expression have...
Sequence databases and transcriptome-wide mapping have revealed different reversible and dynamic che...
Abstract RNA contains over 150 types of chemical modifications. Although many of these chemical modi...
RNA modifications have recently emerged as a widespread and complex facet of gene expression regulat...
Innovations in epitranscriptomics have resulted in the identification of more than 160 RNA modificat...
The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Tr...
Eukaryotic cells utilize a wide range of mechanisms to regulate gene expression, generating divergen...
The broad application of next-generation sequencing technologies in conjunction with improved bioinf...
peer reviewedThe genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and...
In recent years, there has been an increase in research efforts surrounding RNA modification thanks ...