LE SODIUM ET LES MEDICATIONS DE L'INSUFFISANCE CARDIAQUE

The activity of the transport ATPase, responsible for the active transport of the monovalent cations through cell membranes, is decreased in the conductive tissue as compared with the working myocardium. This finding could possibly explain the longer refractory period and the faster spontaneous diastolic depolarization of the conductive tissue. The transport ATPase of the conductive tissue is less sensitive against digitalis glycosides. This might explain the fact that although total transport ATPase is decreased in the conductive tissue, no a v block usually occurs during digitalis therapy.SCOPUS: NotDefined.j