ACTION ANTICOAGULANTE D'UN DERIVE DE SYNTHESE ORIGINAL DE LA 4 HYDROXYCOUMARINE ET ANTAGONISME PAR LA VITAMINE K1 SYNTHETIQUE CHEZ LE RAT

3 {1 [p (2 Chloroethyl)phenyl]butyl} 4 hydroxycoumarin (DB 112) and phenprocoumon, administered orally to Wistar rats, were compared for anticoagulant activity. DB 112 was effective in a single dose smaller than that of phenprocoumon, and with equal doses the effect of DB 112 was greater, and lasted somewhat longer than that of phenprocoumon. In the acute toxicity test (death within 90 min) the LD50 of DB 112 was 1.09-1.32 times that of phenprocoumon. The anticoagulant effect of both drugs was antagonizable by phytomenadione (vitamin K 1). Repeated administration of phytomenadione in suitable dosage made it possible to keep the coagulation time within normal limits and to prevent mortality from hemorrhage under conditions in which the dose of DB 112 used would otherwise have caused death of 90% of the animals in 5-6 days.SCOPUS: NotDefined.j