Add to ORKGIn recent-onset type 1 (insulin-dependent) diabetes mellitus (IDDM), insulin autoantibodies (IAA) and islet cell antibodies (ICA) occur preferentially in young (<10 yr) patients with the HLA DQA1*0301-DQB1*0302 risk haplotype. We investigated whether this association also exists in siblings of IDDM patients. In our group of 310 siblings, aged 0-39 yr, 6% were positive for IAA, 7% for ICA 12 Juvenile Diabetes Foundation units (JDFU) or more, 5% for ICA 20 JDFU or more, and 2% for high titer ICA (≥80 JDFU). The occurrence of IAA and ICA (≥20 JDFU) was significantly associated, with a preferential relationship to the HLA DQA1*0301-DQB1*0302 susceptibility haplotype. In the present group of siblings, IAA and DQA1*0301-DQB1*0302 were significant...
Timing of onset of autoimmunity is a prerequisite for unmasking triggers and pathogenesis of type 1 ...
HLA-associated relative risks of type 1 (insulin-dependent) diabetes mellitus were analysed in popul...
OBJECTIVE: We investigated the effect of HLA class I risk alleles on disease progression in various ...
Two large population-based case-control studies are reviewed. The aim is to determine the effects of...
Aims/hypothesis Islet autoantibodies, in addition to elevated blood glucose, define type 1 diabetes....
AIMS/HYPOTHESIS: Juvenile-onset, insulin-dependent diabetes is associated with islet cell antibodies...
OBJECTIVE We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a ...
AIMS/HYPOTHESIS: Islet autoantibodies, in addition to elevated blood glucose, define type 1 diabetes...
Objectives: We aimed to further characterize demography and genetic associations of type 1 diabetes ...
OBJECTIVE—We evaluated predictors of progression to diabetes in children with high-risk HLA genotype...
Islet autoimmunity is initiated in infancy, and primary prevention trials require children at high g...
OBJECTIVE—We evaluated predictors of progression to diabetes in children with high-risk HLA genotype...
Age-dependent associations between type 1 diabetes risk genes HLA, INS VNTR, and CTLA-4 and autoanti...
OBJECTIVE: We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a...
The objective of this study was to determine the frequencies of autoantibodies to heterogeneous isle...
Timing of onset of autoimmunity is a prerequisite for unmasking triggers and pathogenesis of type 1 ...
HLA-associated relative risks of type 1 (insulin-dependent) diabetes mellitus were analysed in popul...
OBJECTIVE: We investigated the effect of HLA class I risk alleles on disease progression in various ...
Two large population-based case-control studies are reviewed. The aim is to determine the effects of...
Aims/hypothesis Islet autoantibodies, in addition to elevated blood glucose, define type 1 diabetes....
AIMS/HYPOTHESIS: Juvenile-onset, insulin-dependent diabetes is associated with islet cell antibodies...
OBJECTIVE We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a ...
AIMS/HYPOTHESIS: Islet autoantibodies, in addition to elevated blood glucose, define type 1 diabetes...
Objectives: We aimed to further characterize demography and genetic associations of type 1 diabetes ...
OBJECTIVE—We evaluated predictors of progression to diabetes in children with high-risk HLA genotype...
Islet autoimmunity is initiated in infancy, and primary prevention trials require children at high g...
OBJECTIVE—We evaluated predictors of progression to diabetes in children with high-risk HLA genotype...
Age-dependent associations between type 1 diabetes risk genes HLA, INS VNTR, and CTLA-4 and autoanti...
OBJECTIVE: We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a...
The objective of this study was to determine the frequencies of autoantibodies to heterogeneous isle...
Timing of onset of autoimmunity is a prerequisite for unmasking triggers and pathogenesis of type 1 ...
HLA-associated relative risks of type 1 (insulin-dependent) diabetes mellitus were analysed in popul...
OBJECTIVE: We investigated the effect of HLA class I risk alleles on disease progression in various ...