Influence of age on the associations among insulin autoantibodies, islet cell antibodies, and HLA DQA10301-DQB10302 in siblings of Patients with Type 1 (Insulin-Dependent) Diabetes Mellitus

Gorus, Frans
Vandewalle, Christina
Schuit, Frans
Pipeleers, Daniel
Dorchy, Harry
Van Crombrugge, Paul
Becq, Herman
Beirinckx, Joris
Coeckelberghs, Marina
De Leeuw, Ivo
Du Caju, Marc
Van Acker, Karel
Van Gaal, Luc
Vertommen, Jan
Coolens, J.L. J.L.
Craen, Rita
De Cock, Jacques
Rottiers, Raoul
Daubresse, Jean-Claude
Decraene, Paul
Decraene, Tine
De Schepper, Jean
Désir, Daniel
Fery, Françoise
Somers, Guido
Emsens, L.
Herbaut, Christiane
Lemmens, P.
Monballyu, J.
Scheen, André Jacques
Sodoyez, Jean Claude
Van Imschoot, Sylvia

Publication date

May 1994

Abstract

In recent-onset type 1 (insulin-dependent) diabetes mellitus (IDDM), insulin autoantibodies (IAA) and islet cell antibodies (ICA) occur preferentially in young (<10 yr) patients with the HLA DQA1*0301-DQB1*0302 risk haplotype. We investigated whether this association also exists in siblings of IDDM patients. In our group of 310 siblings, aged 0-39 yr, 6% were positive for IAA, 7% for ICA 12 Juvenile Diabetes Foundation units (JDFU) or more, 5% for ICA 20 JDFU or more, and 2% for high titer ICA (≥80 JDFU). The occurrence of IAA and ICA (≥20 JDFU) was significantly associated, with a preferential relationship to the HLA DQA1*0301-DQB1*0302 susceptibility haplotype. In the present group of siblings, IAA and DQA1*0301-DQB1*0302 were significant...

Extracted data

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Influence of age on the associations among insulin autoantibodies, islet cell antibodies, and HLA DQA10301-DQB10302 in siblings of Patients with Type 1 (Insulin-Dependent) Diabetes Mellitus

Gorus, Frans
Vandewalle, Christina
Schuit, Frans
Pipeleers, Daniel
Dorchy, Harry
Van Crombrugge, Paul
Becq, Herman
Beirinckx, Joris
Coeckelberghs, Marina
De Leeuw, Ivo
Du Caju, Marc
Van Acker, Karel
Van Gaal, Luc
Vertommen, Jan
Coolens, J.L. J.L.
Craen, Rita
De Cock, Jacques
Rottiers, Raoul
Daubresse, Jean-Claude
Decraene, Paul
Decraene, Tine
De Schepper, Jean
Désir, Daniel
Fery, Françoise
Somers, Guido
Emsens, L.
Herbaut, Christiane
Lemmens, P.
Monballyu, J.
Scheen, André Jacques
Sodoyez, Jean Claude
Van Imschoot, Sylvia

Open link

Publication date

May 1994

Abstract

Extracted data

Graham, J
Hagopian, WA
Kockum, I
Li, LS
Sanjeevi, CB
Lowe, RM
Schaefer, JB
Zarghami, M
Day, HL
Landin-Olsson, Mona
Palmer, JP
Janer-Villanueva, M
Hood, L
Sundkvist, G
Lernmark, Åke
Breslow, N
Dahlquist, G
Blohme, G

January 2002

Age-dependent associations between type 1 diabetes risk genes HLA, INS VNTR, and CTLA-4 and autoanti...

Twenty-Year Progression Rate to Clinical Onset According to Autoantibody Profile, Age, and HLA-DQ Genotype in a Registry-Based Group of Children and Adults With a First-Degree Relative With Type 1 Diabetes

Gorus, Frans K
Balti, Eric V
Messaaoui, Anissa
Demeester, Simke
Van Dalem, Annelien
Costa, Olivier
Dorchy, Harry
Mathieu, Chantal
Van Gaal, Luc
Keymeulen, Bart
Pipeleers, Daniel G
Weets, Ilse

August 2017

OBJECTIVE: We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a...

Autoantibodies and High-Risk HLA Susceptibility Markers in First-Degree Relatives of Brazilian Patients with Type 1 Diabetes Mellitus: A Progression to Disease Based Study

Alves, L. I.
Davini, E.
Correia, M. R.
Fukui, R. T.
Santos, R. F.
Cunha, M. R.
Rocha, D. M.
Volpini, W. M. G.
Silva, M. E. R.

January 2012

The objective of this study was to determine the frequencies of autoantibodies to heterogeneous isle...

Genetic and immunological findings in patients with newly diagnosed insulin-dependent diabetes mellitus

Kockum, Ingrid
Lernmark, Å
Dahlquist, Gisela
Falorni, A.
Hagopian, W. A.
Landin-Olsson, Mona
Li, L. C.
Luthman, H.
Palmer, J. P.
Sanjeevi, C. B.
Sundkvist, G.
Östman, J.
Swedish Childhood Diabetes Study Group

January 1996

Two large population-based case-control studies are reviewed. The aim is to determine the effects of...

Genetic and immunological findings in patients with newly diagnosed insulin-dependent diabetes mellitus

Kockum, Ingrid
Lernmark, Å
Dahlquist, Gisela
Falorni, A.
Hagopian, W. A.
Landin-Olsson, Mona
Li, L. C.
Luthman, H.
Palmer, J. P.
Sanjeevi, C. B.
Sundkvist, G.
Östman, J.
Swedish Childhood Diabetes Study Group

January 1996

Two large population-based case-control studies are reviewed. The aim is to determine the effects of...

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study

Krischer, Jeffrey P.
Lynch, Kristian F.
Schatz, Desmond A.
Ilonen, Jorma
Lernmark, Åke
Hagopian, William A.
Rewers, Marian J.
She, Jin-Xiong
Simell, Olli G.
Toppari, Jorma
Ziegler, Anette-G.
Akolkar, Beena
Bonifacio, Ezio

January 2015

Aims/hypothesis Islet autoantibodies, in addition to elevated blood glucose, define type 1 diabetes....

Twenty-year progression rate to clinical onset according to autoantibody profile, age, and HLA-dq genotype in a registry-based group of children and adults with a first-degree relative with type 1 diabetes

Gorus, Frans
Keymeulen, Bart
Pipeleers, Daniel
Weets, Ilse
Balti, Eric E.V.
Messaaoui, Anissa
Demeester, Simke
Van Dalem, Annelien
Costa, Olivier
Dorchy, Harry
Mathieu, Chantal
Van Gaal, Luc

August 2017

OBJECTIVE We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a ...

Gorus, Frans
Keymeulen, Bart
Pipeleers, Daniel
Weets, Ilse
Balti, Eric E.V.
Messaaoui, Anissa
Demeester, Simke
Van Dalem, Annelien
Costa, Olivier
Dorchy, Harry
Mathieu, Chantal
Van Gaal, Luc

August 2017

OBJECTIVE We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a ...

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: The TEDDY study.

Krischer, J.P.
Lynch, K.F.
Schatz, D.A.
Ilonen, J.
Lernmark, A.
Hagopian, W.A.
Rewers, M.J.
She, J.X.
Simell, O.G.
Toppari, J.
Ziegler, A.-G.
Akolkar, B.
Bonifacio, E.
TEDDY Study Group (Beyerlein, A.

January 2015

AIMS/HYPOTHESIS: Islet autoantibodies, in addition to elevated blood glucose, define type 1 diabetes...

Associations between deduced first islet specific autoantibody with sex, age at diagnosis and genetic risk factors in young children with type 1 diabetes

Ilonen, Jorma
Laine, Antti Pekka
Kiviniemi, Minna
Härkönen, Taina
Lempainen, Johanna
Knip, Mikael
The Finnish Pediatric Diabetes Register

April 2022

Objectives: We aimed to further characterize demography and genetic associations of type 1 diabetes ...

Associations between deduced first islet specific autoantibody with sex, age at diagnosis and genetic risk factors in young children with type 1 diabetes

Ilonen, Jorma
Laine, Antti Pekka
Kiviniemi, Minna
Härkönen, Taina
Lempainen, Johanna
Knip, Mikael
The Finnish Pediatric Diabetes Register

April 2022

Objectives: We aimed to further characterize demography and genetic associations of type 1 diabetes ...

Age of Islet Autoantibody Appearance andMean Levels of Insulin, But Not GAD or IA-2 Autoantibodies, Predict Age of Diagnosis of Type 1 Diabetes Diabetes Autoimmunity Study in the Young

Andrea K. Steck
Kelly Johnson Bs
Katherine J. Barriga
John C. Hutton
George S. Eisenbarth
Marian J. Rewers

September 2016

OBJECTIVE—We evaluated predictors of progression to diabetes in children with high-risk HLA genotype...

Age of Islet Autoantibody Appearance andMean Levels of Insulin, but Not GAD or IA-2 Autoantibodies, Predict Age of Diagnosis of Type 1 Diabetes Diabetes Autoimmunity Study in the Young

Andrea K. Steck
Kelly Johnson Bs
Katherine J. Barriga
John C. Hutton
George S. Eisenbarth
Marian J. Rewers

September 2016

OBJECTIVE—We evaluated predictors of progression to diabetes in children with high-risk HLA genotype...

Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.

Graham, J
Hagopian, WA
Kockum, I
Li, LS
Sanjeevi, CB
Lowe, RM
Schaefer, JB
Zarghami, M
Day, HL
Landin-Olsson, Mona
Palmer, JP
Janer-Villanueva, M
Hood, L
Sundkvist, G
Lernmark, Åke
Breslow, N
Dahlquist, G
Blohme, G

January 2002

Age-dependent associations between type 1 diabetes risk genes HLA, INS VNTR, and CTLA-4 and autoanti...

Gorus, Frans K
Balti, Eric V
Messaaoui, Anissa
Demeester, Simke
Van Dalem, Annelien
Costa, Olivier
Dorchy, Harry
Mathieu, Chantal
Van Gaal, Luc
Keymeulen, Bart
Pipeleers, Daniel G
Weets, Ilse

August 2017

OBJECTIVE: We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a...

Autoantibodies and High-Risk HLA Susceptibility Markers in First-Degree Relatives of Brazilian Patients with Type 1 Diabetes Mellitus: A Progression to Disease Based Study

Alves, L. I.
Davini, E.
Correia, M. R.
Fukui, R. T.
Santos, R. F.
Cunha, M. R.
Rocha, D. M.
Volpini, W. M. G.
Silva, M. E. R.

January 2012

The objective of this study was to determine the frequencies of autoantibodies to heterogeneous isle...

Genetic and immunological findings in patients with newly diagnosed insulin-dependent diabetes mellitus

Kockum, Ingrid
Lernmark, Å
Dahlquist, Gisela
Falorni, A.
Hagopian, W. A.
Landin-Olsson, Mona
Li, L. C.
Luthman, H.
Palmer, J. P.
Sanjeevi, C. B.
Sundkvist, G.
Östman, J.
Swedish Childhood Diabetes Study Group

January 1996

Two large population-based case-control studies are reviewed. The aim is to determine the effects of...

Genetic and immunological findings in patients with newly diagnosed insulin-dependent diabetes mellitus

Kockum, Ingrid
Lernmark, Å
Dahlquist, Gisela
Falorni, A.
Hagopian, W. A.
Landin-Olsson, Mona
Li, L. C.
Luthman, H.
Palmer, J. P.
Sanjeevi, C. B.
Sundkvist, G.
Östman, J.
Swedish Childhood Diabetes Study Group

January 1996

Two large population-based case-control studies are reviewed. The aim is to determine the effects of...

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study

Krischer, Jeffrey P.
Lynch, Kristian F.
Schatz, Desmond A.
Ilonen, Jorma
Lernmark, Åke
Hagopian, William A.
Rewers, Marian J.
She, Jin-Xiong
Simell, Olli G.
Toppari, Jorma
Ziegler, Anette-G.
Akolkar, Beena
Bonifacio, Ezio

January 2015

Aims/hypothesis Islet autoantibodies, in addition to elevated blood glucose, define type 1 diabetes....

Gorus, Frans
Keymeulen, Bart
Pipeleers, Daniel
Weets, Ilse
Balti, Eric E.V.
Messaaoui, Anissa
Demeester, Simke
Van Dalem, Annelien
Costa, Olivier
Dorchy, Harry
Mathieu, Chantal
Van Gaal, Luc

August 2017

OBJECTIVE We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a ...

Gorus, Frans
Keymeulen, Bart
Pipeleers, Daniel
Weets, Ilse
Balti, Eric E.V.
Messaaoui, Anissa
Demeester, Simke
Van Dalem, Annelien
Costa, Olivier
Dorchy, Harry
Mathieu, Chantal
Van Gaal, Luc

August 2017

OBJECTIVE We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a ...

The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: The TEDDY study.

Krischer, J.P.
Lynch, K.F.
Schatz, D.A.
Ilonen, J.
Lernmark, A.
Hagopian, W.A.
Rewers, M.J.
She, J.X.
Simell, O.G.
Toppari, J.
Ziegler, A.-G.
Akolkar, B.
Bonifacio, E.
TEDDY Study Group (Beyerlein, A.

January 2015

AIMS/HYPOTHESIS: Islet autoantibodies, in addition to elevated blood glucose, define type 1 diabetes...

Associations between deduced first islet specific autoantibody with sex, age at diagnosis and genetic risk factors in young children with type 1 diabetes

Ilonen, Jorma
Laine, Antti Pekka
Kiviniemi, Minna
Härkönen, Taina
Lempainen, Johanna
Knip, Mikael
The Finnish Pediatric Diabetes Register

April 2022

Objectives: We aimed to further characterize demography and genetic associations of type 1 diabetes ...

Associations between deduced first islet specific autoantibody with sex, age at diagnosis and genetic risk factors in young children with type 1 diabetes

Ilonen, Jorma
Laine, Antti Pekka
Kiviniemi, Minna
Härkönen, Taina
Lempainen, Johanna
Knip, Mikael
The Finnish Pediatric Diabetes Register

April 2022

Objectives: We aimed to further characterize demography and genetic associations of type 1 diabetes ...

Age of Islet Autoantibody Appearance andMean Levels of Insulin, But Not GAD or IA-2 Autoantibodies, Predict Age of Diagnosis of Type 1 Diabetes Diabetes Autoimmunity Study in the Young

Andrea K. Steck
Kelly Johnson Bs
Katherine J. Barriga
John C. Hutton
George S. Eisenbarth
Marian J. Rewers

September 2016

OBJECTIVE—We evaluated predictors of progression to diabetes in children with high-risk HLA genotype...

Age of Islet Autoantibody Appearance andMean Levels of Insulin, but Not GAD or IA-2 Autoantibodies, Predict Age of Diagnosis of Type 1 Diabetes Diabetes Autoimmunity Study in the Young

Andrea K. Steck
Kelly Johnson Bs
Katherine J. Barriga
John C. Hutton
George S. Eisenbarth
Marian J. Rewers

September 2016

OBJECTIVE—We evaluated predictors of progression to diabetes in children with high-risk HLA genotype...

Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.

Graham, J
Hagopian, WA
Kockum, I
Li, LS
Sanjeevi, CB
Lowe, RM
Schaefer, JB
Zarghami, M
Day, HL
Landin-Olsson, Mona
Palmer, JP
Janer-Villanueva, M
Hood, L
Sundkvist, G
Lernmark, Åke
Breslow, N
Dahlquist, G
Blohme, G

January 2002

Age-dependent associations between type 1 diabetes risk genes HLA, INS VNTR, and CTLA-4 and autoanti...

Gorus, Frans K
Balti, Eric V
Messaaoui, Anissa
Demeester, Simke
Van Dalem, Annelien
Costa, Olivier
Dorchy, Harry
Mathieu, Chantal
Van Gaal, Luc
Keymeulen, Bart
Pipeleers, Daniel G
Weets, Ilse

August 2017

OBJECTIVE: We investigated whether islet autoantibody profile, HLA-DQ genotype, and age influenced a...

Autoantibodies and High-Risk HLA Susceptibility Markers in First-Degree Relatives of Brazilian Patients with Type 1 Diabetes Mellitus: A Progression to Disease Based Study

Alves, L. I.
Davini, E.
Correia, M. R.
Fukui, R. T.
Santos, R. F.
Cunha, M. R.
Rocha, D. M.
Volpini, W. M. G.
Silva, M. E. R.

January 2012

The objective of this study was to determine the frequencies of autoantibodies to heterogeneous isle...

Influence of age on the associations among insulin autoantibodies, islet cell antibodies, and HLA DQA10301-DQB10302 in siblings of Patients with Type 1 (Insulin-Dependent) Diabetes Mellitus

Abstract

Extracted data

Influence of age on the associations among insulin autoantibodies, islet cell antibodies, and HLA DQA10301-DQB10302 in siblings of Patients with Type 1 (Insulin-Dependent) Diabetes Mellitus

Abstract

Extracted data

Related items

Related items

Influence of age on the associations among insulin autoantibodies, islet cell antibodies, and HLA DQA1*0301-DQB1*0302 in siblings of Patients with Type 1 (Insulin-Dependent) Diabetes Mellitus

Abstract

Extracted data

Influence of age on the associations among insulin autoantibodies, islet cell antibodies, and HLA DQA1*0301-DQB1*0302 in siblings of Patients with Type 1 (Insulin-Dependent) Diabetes Mellitus

Abstract

Extracted data

Related items

Related items

Influence of age on the associations among insulin autoantibodies, islet cell antibodies, and HLA DQA10301-DQB10302 in siblings of Patients with Type 1 (Insulin-Dependent) Diabetes Mellitus

Influence of age on the associations among insulin autoantibodies, islet cell antibodies, and HLA DQA10301-DQB10302 in siblings of Patients with Type 1 (Insulin-Dependent) Diabetes Mellitus