In multiple myeloma (MM), bone marrow mesenchymal stromal cells (BM-MSCs) play an important role in pathogenesis and disease progression by supporting myeloma cell growth and immune escape. Previous studies have suggested that direct and indirect interactions between malignant cells and BM-MSCs result in constitutive abnormal immunomodulatory capacities in MM BM-MSCs. The aim of this study was to investigate the mechanisms that underlie these MM BM-MSCs abnormalities. We demonstrated that MM BM-MSCs exhibit abnormal expression of CD40/40L, VCAM1, ICAM-1, LFA-3, HO-1, HLA-DR and HLA-ABC. Furthermore, an overproduction of IL-6 (1,806 ± 152.5 vs 719.6 ± 18.22 ng/mL; p = 0.035) and a reduced secretion of IL-10 (136 ± 15.02 vs 346.4 ± 35.32 ng/m...
The immunological bone marrow (BM) microenvironment plays a major role in controlling growth and sur...
In multiple myeloma (MM), dendritic cells (DCs), and their precursors are prone to malignant cell-me...
In multiple myeloma (MM), dendritic cells (DCs), and their precursors are prone to malignant cell-me...
© 2021 by the authors.Multiple myeloma (MM) is a hematological malignancy of plasma cells that proli...
International audienceRecent literature suggested that cells of the microenvironment of tumors could...
We have verified the hypothesis that multiple myeloma (MM) may be disseminated by circulating clonog...
Multiple myeloma (MM) is a tumor of terminally differentiated B cells that arises in the bone marrow...
Multiple myeloma (MM) is a plasma cell malignancy that presents with bone marrow plasmacytosis, mono...
Although multiple myeloma (MM) is characterized by a monoclonal expansion of plasma cells, it has be...
Multiple Myeloma (MM) is a systemic hematologic disease due to uncontrolled proliferation of monoclo...
Multiple myeloma (MM) is a plasma cell malignancy where MM cell growth is supported by the bone marr...
Multiple myeloma (MM) is a dyscrasia of plasma cells (PCs) characterized by abnormal immunoglobulin ...
Multiple myeloma (MM) is the second most common hematologic malignancy, characterized by a multi-ste...
Purpose Immune dysregulation is described in multiple myeloma. While preclinical models suggest a ro...
Multiple myeloma (MM) is a hematological malignancy of plasma cells that proliferate and accumulate ...
The immunological bone marrow (BM) microenvironment plays a major role in controlling growth and sur...
In multiple myeloma (MM), dendritic cells (DCs), and their precursors are prone to malignant cell-me...
In multiple myeloma (MM), dendritic cells (DCs), and their precursors are prone to malignant cell-me...
© 2021 by the authors.Multiple myeloma (MM) is a hematological malignancy of plasma cells that proli...
International audienceRecent literature suggested that cells of the microenvironment of tumors could...
We have verified the hypothesis that multiple myeloma (MM) may be disseminated by circulating clonog...
Multiple myeloma (MM) is a tumor of terminally differentiated B cells that arises in the bone marrow...
Multiple myeloma (MM) is a plasma cell malignancy that presents with bone marrow plasmacytosis, mono...
Although multiple myeloma (MM) is characterized by a monoclonal expansion of plasma cells, it has be...
Multiple Myeloma (MM) is a systemic hematologic disease due to uncontrolled proliferation of monoclo...
Multiple myeloma (MM) is a plasma cell malignancy where MM cell growth is supported by the bone marr...
Multiple myeloma (MM) is a dyscrasia of plasma cells (PCs) characterized by abnormal immunoglobulin ...
Multiple myeloma (MM) is the second most common hematologic malignancy, characterized by a multi-ste...
Purpose Immune dysregulation is described in multiple myeloma. While preclinical models suggest a ro...
Multiple myeloma (MM) is a hematological malignancy of plasma cells that proliferate and accumulate ...
The immunological bone marrow (BM) microenvironment plays a major role in controlling growth and sur...
In multiple myeloma (MM), dendritic cells (DCs), and their precursors are prone to malignant cell-me...
In multiple myeloma (MM), dendritic cells (DCs), and their precursors are prone to malignant cell-me...