We describe a preliminary retrospective study based on the concentration of two hydroxylated metabolites of oxcarbazepine (OCZ), a new anticonvulsant substance, measured in the plasma of 15 patients with epilepsy. Their ages ranged from 8 to 68 years, 6 of them also received phenobarbital and/or phenytoin as co-medication. The concentration of 10-hydroxy-10,11-dihydrocarbamazepine (HCBZ) or of trans-10,11-dihydroxy-10,11- dihydrocarbamazepine (DHCBZ), the metabolites measured, are significantly correlated with the dose of OCZ (p<0.05 and p<0.01, respectively). DHCBZ concentrations, standardized to a constant OCZ dose or to a constant HCBZ concentration, are significantly higher during co-medication (p<0.01 and p<0.05, respectively); HCBZ le...
International audienceAimsOxcarbazepine is an antiepileptic drug with an activity mostly due to its ...
BACKGROUND AND OBJECTIVES: Oxcarbazepine is a new antiepileptic drug which in humans acts as a prodr...
International audienceAimsOxcarbazepine is an antiepileptic drug with an activity mostly due to its ...
The pharmacokinetics of oxcarbazepine (a new anticonvulsant which is a congener of carbamazepine) an...
Oxcarbazepine is a new anticonvulsant, currently undergoing clinical trials. Its spectrum of antiepi...
The kinetics of oxcarbazepine (OXC) and its active metabolite 10-hydroxy-carbazepine (10-OH-CZ) afte...
Hepatic oxygenases of the cytochrome P-450 family play a major role in the clearance of various anti...
To investigate the relationship between the serum concentration of the mono-hydroxy-derivative (MHD)...
The aim of this study was to investigate the relationships between oxcarbazepine (OXC) dosage, metab...
AbstractPurposeTo evaluate the relationship between serum concentrations of mono-hydroxy-carbazepine...
Continuing experience with oxcarbazepine has shown that the drug tends to be less sedative than carb...
PURPOSE: To investigate the relationship between the serum concentration of the mono-hydroxy-derivat...
PURPOSE: To investigate the relationship between the serum concentration of the mono-hydroxy-derivat...
AbstractPurposeTo evaluate the relationship between serum concentrations of mono-hydroxy-carbazepine...
International audienceAimsOxcarbazepine is an antiepileptic drug with an activity mostly due to its ...
International audienceAimsOxcarbazepine is an antiepileptic drug with an activity mostly due to its ...
BACKGROUND AND OBJECTIVES: Oxcarbazepine is a new antiepileptic drug which in humans acts as a prodr...
International audienceAimsOxcarbazepine is an antiepileptic drug with an activity mostly due to its ...
The pharmacokinetics of oxcarbazepine (a new anticonvulsant which is a congener of carbamazepine) an...
Oxcarbazepine is a new anticonvulsant, currently undergoing clinical trials. Its spectrum of antiepi...
The kinetics of oxcarbazepine (OXC) and its active metabolite 10-hydroxy-carbazepine (10-OH-CZ) afte...
Hepatic oxygenases of the cytochrome P-450 family play a major role in the clearance of various anti...
To investigate the relationship between the serum concentration of the mono-hydroxy-derivative (MHD)...
The aim of this study was to investigate the relationships between oxcarbazepine (OXC) dosage, metab...
AbstractPurposeTo evaluate the relationship between serum concentrations of mono-hydroxy-carbazepine...
Continuing experience with oxcarbazepine has shown that the drug tends to be less sedative than carb...
PURPOSE: To investigate the relationship between the serum concentration of the mono-hydroxy-derivat...
PURPOSE: To investigate the relationship between the serum concentration of the mono-hydroxy-derivat...
AbstractPurposeTo evaluate the relationship between serum concentrations of mono-hydroxy-carbazepine...
International audienceAimsOxcarbazepine is an antiepileptic drug with an activity mostly due to its ...
International audienceAimsOxcarbazepine is an antiepileptic drug with an activity mostly due to its ...
BACKGROUND AND OBJECTIVES: Oxcarbazepine is a new antiepileptic drug which in humans acts as a prodr...
International audienceAimsOxcarbazepine is an antiepileptic drug with an activity mostly due to its ...