Radiosensitization by cytotoxic drugs. The EORTC experience by the Radiotherapy and Lung Cancer Cooperative Groups
- Schaake-Koning, Caro C E C.
- Dalesio, Otilia
- Van Zandwijk, Nico
- Bartelink, Harry
- Van den Bogaert, Walter
- Rodrigus, Patrick
- Festen, Jan J M J.
- Hoogenhout, Jaap
- Van Houtte, Paul
- Sculier, Jean-Paul
- Kirkpatrick, Anne
- Koolen, Mia GJ J M.
- Schuster-Uitterhoeve, Lon
- Maat, Ben
- Nijs, Arie
- Renaud, Alain
DOIAbstract
A three-arm randomized trial was performed to assess the acute and late toxicity and the impact on survival of the combination high-dose, split-course radiotherapy with 30 mg/m2 cisplatin (cDDP) weekly, with 6 mg/m2 cisplatin daily compared to radiotherapy alone in patients with non-small cell lung cancer (NSCLC). The study started in May 1984 and was closed in May 1989 after 331 patients were randomised. The analysis was performed after a minimum follow-up period of 22 months. Radiotherapy (RT) consisted of 30 Gy, 10 fractions, five fractions a week; then a 3-week split followed by 25 Gy in 10 fractions. © 1994.SCOPUS: ar.jinfo:eu-repo/semantics/publishe
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