Étude autoradiographique de l'incorporation dans le foie de souris de précurseurs des acides nucléiques et des protéines

The in vivo incorporation of glycine-1-14C, dl-phenylalanine-3-14C and adenine-8-14C in mouse liver has been studied by radioautography. Results may be given quantitatively and are in fair agreement with those obtained by the usual biochemical methods. However, in the case of all three precursors, we have found a metabolic activity of the nuclei of liver cells about 4 times that of the cytoplasm. The nuclei of the Kupffer cells have a still greater activity. We have investigated systematically by the same technique the properties of various fixatives. © 1955.SCOPUS: ar.j