Prothrombin Brussels, a new congenital defective protein

Some properties of a new congenital abnormality of the prothrombin molecule are described. In the propositus' plasma, the prothrombin level is half normal plasma concentration estimated in the one and two stage test and in the staphylocoagulase assay but it is in the normal range by the immunochemical assay. This abnormal prothrombin is modified during coagulation into a form that enables it to react with staphylocoagulase but not with prothrombinase. The immunoelectrophoresis of the serum reveals an abnormal pattern. The defect is found in one of the propositus' brothers. © 1974.SCOPUS: ar.j