Somatostatin analogues containing o-aminomethylphenylacetic acid as a bridge unit

A new cis-peptide bond mimetic, α-benzyl-o-aminomethylphenylacetic acid, was synthesized and incorporated in a homodetic somatostatin analogue. Biological binding tests and 2D NMR conformational analysis indicate that the configuration of the bridge-unit asymmetric center and the orientation of the benzyl side chain play a key role in the biological activity of this type of somatostatin analogues. © 1995 ESCOM Science Publishers B.V.SCOPUS: ar.j